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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Risperidone Subcutaneous Implant

    SBC: DELPOR INC            Topic: 101

    The objective of the proposed study is to develop a subcutaneous implant of risperidone that provides consistent therapeutic blood levels of the drug for 6 months after a single administration. The device is implanted during a simple, 10-minute, in-office procedure with local anesthetic. The benefits of the product include improved medication adherence, fewer relapses, ability to withdraw the medi ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  2. Clinical Vector for TCR Immunotherapy Targeted to Melanoma

    SBC: LENTIGEN CORPORATION            Topic: NCI

    DESCRIPTION (provided by applicant): This Phase II proposal is a continuation of our Phase I award, Lentiviral Vectors for TCR Immunotherapy Targeted to Melanoma. We have successfully achieved the milestones laid out in our initial application. We generated a lentiviral gene vector capable of expressing a T cell receptor (TCR) specific for the tyrosinase:368-376 epitope, and demonstrated the act ...

    SBIR Phase II 2010 Department of Health and Human ServicesNational Institutes of Health
  3. Populating MPS database with data from multi-organ, human-on-a-chip microphysiological systems

    SBC: HESPEROS, INC            Topic: 100

    Project Summary/Abstract: As stated in the Notice of Special Interest announcement, there is a need to populate the recently established MPS database with existing data generated by organ-on-a-chip systems. Having a centralized, public database with data from all available MPS systems will accelerate development and acceptance of the technology ultimately bringing better therapies to patients fast ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  4. A Phase 2b Clinical Trial to Study the Efficacy of Longeveron Mesenchymal Stem Cells (LMSCs) to Treat Aging Frailty

    SBC: Longeveron LLC            Topic: NIA

    Aging Frailty is a biologically driven geriatric syndrome of multisystem physiological decline that is distinct from normal aging and disproportionately increases vulnerability to adverse clinical outcomes. Frailty has an overall prevalence of 10% of those 65 years and older, and there is growing awareness in the geriatric community to diagnose and treat this condition, as it is not an inevitable ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  5. Developing and Evaluating In-Home Supportive Technology for Dementia Caregivers

    SBC: PEOPLE POWER COMPANY            Topic: NIA

    AbstractCaring for a loved one with Alzheimer’s disease, frontotemporal dementia, or another neurodegenerative disease is a highly meaningful part of family life. However, the associated burden and strain can have adverse effects on caregivers including mental and physical health problems, reduced well-being, and increased mortality. These effects, in turn, can compromise care quality and shorte ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  6. Development of VLP vaccine for RSV

    SBC: SIGMOVIR BIOSYSTEMS, INC.            Topic: NIAID

    Respiratory syncytial virus (RSV) is a significant human pathogen severely impacting neonates and young children, but no vaccine exists to protect this vulnerable population. Furthermore, direct vaccination of neonates is likely ineffective due to the immaturity of their immune system, and neonate immunization is potentially unsafe. The current view is that maternal vaccination is the best and saf ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  7. Device to control circadian-effective light in Alzheimer's disease environments

    SBC: Blue Iris Labs            Topic: NIA

    Project Summary This proposed project will develop and field-test a device that accurately monitors and controls the circadian stimulus (CS) for Alzheimer disease (AD) and Alzheimer-disease-related dementia (ADRD) patients in nursing homes. Human biology has evolved to have two distinct optical systems: the visual system, by which we see and process images, and the circadian system, which regulate ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  8. Rapid and Simple Paper Strip Test for the Multiplexed Detection of Gastrointestinal Pathogens at the Point-of-Need

    SBC: Godx Inc.            Topic: 950

    PROJECT SUMMARY GoDx, Inc. has been developing a prototype multiplexed paper strip device for the detection of the DNA and RNA of gastrointestinal pathogens at the point-of-need in andlt; 30 minutes with funding from the NCATS SBIR parent grant TR 001912. We have used the same platform technology we are developing in the parent grant to develop a rapid (andlt;30 minute), low-cost and instrument-fr ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  9. TUMOR RADIOSENSITIZATION USING A NITRIC-OXIDE-NEUTRAL, TUNABLE OXYGEN-BINDING PRO

    SBC: OMNIOX INC            Topic: NCI

    DESCRIPTION (provided by applicant): Low oxygen conditions (hypoxia) commonly found in solid tumors are considered a major obstacle for the clinical management of cancer by radiation therapy (radiotherapy, RT). Moreover, cancer patients with significantly hypoxic tumors tend to have a poor prognosis for survival. Given the clinical relevance of hypoxia, a long-time objective of experimental RT res ...

    SBIR Phase II 2010 Department of Health and Human ServicesNational Institutes of Health
  10. A scalable system for high-throughput and longitudinal electrophysiology in rodent brain research

    SBC: SPIKEGADGETS, INC.            Topic: 101

    Psychiatric disorders give rise to aberrant patterns of activity within the complex neural circuits of our brains. Yet, the exact nature of these abnormal patterns is often unknown to developers of new treatments. The goal of this project is to enable circuit-oriented research of neuropsychiatric diseases using rodent disease models. The long-term objective is to catalyze the discovery of new ther ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
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