Award Data

The goal of the Environment, Epidemiology, and Etiology Surveillance and Analysis Toolkit (E3SAT) project is to develop a data analysis infrastructure, models and templates to facilitate environmental, epidemiological and etiological analysis. E3SAT provides a research data cube and analysis tool suite that allows researchers to collect, integrate and data mine medical information, environmental ...

Current methods to discern the differentiation state of stem cells are time-consuming, labor-intensive, costly, invasive, and consequently, ill-suited for clinical applications. To overcome these limitations, we propose to develop a microfluidic stem cell analyzer for accurate, non-invasive identification of the cell differentiation state in conjunction with automated cell sorting at high-throughp ...

Existing clinical decision support systems (CDSS) for TBI/PTSD are not well integrated with clinical pathways, terminologies/codes, and/or electronic medical records. Further, these CDSS do not leverage the latest computing technologies such as cloud computing, speech recognition, mobile computing and NLP. In particular, latest advances in machine learning / predictive analytics are not utilized. ...

We propose to design and develop a Cohort Development and Analysis Toolkit (CDAT) that will assist clinicians, practice administrators and public health professionals in comparing the effectiveness of different clinical practices, including preventive and treatment modalities. The overall goal of CDAT is to facilitate comparative effectiveness research and evidence-based practice without the nece ...

Peripheral Neuropathy (PN) is a painful debilitating condition caused by progressive subcutaneous nerve damage due to diabetes, chemotherapy or as a result of traumatic combat injuries. Systemic or topical administration of existing therapeutics alleviates pain but does not address progressive nerve damage. High dosages requisite for therapeutic effect increase long-term toxicity risk. Lynntech ...

Mild traumatic brain injury (mTBI) is associated with emotional and physical health problems, of which PTSD and depression are important mediators. Our Phase I research created a conceptual model for a user-friendly, empirically-based screening/tracking tool available to first responders and medical practitioners to screen for mTBI or other disorders. We assessed the co-occurrence of these co-mo ...

Operational Technologies Corporation (OpTech) has completed a successful Phase I SBIR contract in which 72 new candidate DNA aptamer sequences against Leishmania major were developed and screened by ELISA-like plate assay. Several pilot assays were developed from the highest affinity candidate aptamers using a commercially available handheld and battery-operated fluorometer. In Phase II, OpTech p ...

Cornerstone Research Group Inc. (CRG) proposes to redefine the immobilization and evacuation of SCI and TBI patients by developing a new patient stabilization system for aeromedical transport. This system will properly immobilize patients in a variety of transport configurations and reduce dynamic flight effects. CRG"s design will decrease co-morbidity associated with improper immobilization of SC ...

MedWorld will apply virtual world gaming techniques to enable military medical personnel to experience the impact of real world conditions in performance of their duties, whether they are on the battlefield or in a stateside hospital. MedWorld is struc

This proposal will address the needs described in sub-topic OSD10-H05 ("Deployable Automated Analgesia and Anesthesia System"), by developing the AutoTIVATM, a portable closed-loop anesthesia system based on non-invasive cortical monitoring. This system w