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Cell-free platforms are a disruptive technology that can dramatically speed up the design-build-test cycle of biomolecular engineering. However, most currently available cell-free platforms are optimized for protein expression rather than for prototyping. Synvitrobio proposes to develop and commercialize a next-generation cell-free platform that allows for rapid, low-cost, high-throughput, and rep ...

Graph analytics have emerged as a prominent computational workload in the defense community, and are representative of fundamental kernels in national security applications. Processing speed is a fundamental requirement for these applications. Massively-parallel hardware architectures promise to increase the performance of graph analytics. However, significant improvements in software technologies ...

To address the Chemical and Biological Defense programs (CBDs) need for medical countermeasures against mycotoxin intoxication, PhysicalOptics Corporation (POC) proposes to develop a new Mycotoxin Neutralization Treatment (MyNT). This proposed solution is based on neutralizingmycotoxin from its deleterious effects by acting on multiple levels of mycotoxin metabolism through the novel combination o ...

Acute exposure to mycotoxins can lead to systemic toxicity and even death. With no specific treatment available, aflatoxin and trichothecene T-2toxin, in particular, are of concern as potential biological weapons due to their toxicity, thermal and UV stability and easy accessibility. As amedical countermeasure, we propose the development of highly porous polymer beads optimized for removal of afla ...

Aflatoxins are a paradigm among fungal produced mycotoxins that are present in food supplies and are strongly associated with increased risk forthe development of hepatocellular carcinoma. Currently, there are no known countermeasures that can selectively mitigate aflatoxin toxicity andthe available options are only symptomatic treatments. To meet this challenge, we propose to harness the microbio ...

Based on encouraging Phase I feasibility results, we propose developing a novel gene therapy approach to promote guided vascular regeneration in treating extremities after traumatic injury. Our approach is to provide thread-like implants comprised of aligned nanofibrillar collagen scaffolds loaded with Hepatocyte Growth Factor (HGF) vectors (e.g., HGF DNA plasmid, modified mRNA) designed to enhanc ...

We propose to develop a high-resolution soft x-ray nanoscope based on Fourier Transform Holography which has the very important advantage for real time visualization: 3D images are nearly instantaneously retrieved with a simple 2D Fast Fourier Transform operation. The table-top soft x-ray nanoscope will use for illumination a compact high average power soft x-ray laser that generates high e ...

The objective is to design an analog (time-continuous) radiofrequency (RF) computation platform in the form of a software-defined RF integrated-circuit (IC) with supplementary digital logic for solving differential equation based simulations at speeds that are 1-2 orders of magnitude greater than available digital high-performance computation platforms. The maximum speed that the state-of-the-art ...

It has long been known that analog computers can be faster and more power efficient than digital processors by many orders of magnitude. Until the 1970s analog computers were the dominant controllers in most industrial and military applications. Even today digital processors are still slower and more power consumptive than analog, but offer much more flexibility (programmability) and precision. ...

The ready availability of universal donor plasma to rapidly treat massively bleeding hospital trauma patients and warfighters with combat casualties is a key element of current recommendations for trauma resuscitation, yet universal AB donor plasma is rel