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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. rAAV5-hCNGB3 Gene Therapy for Achromatopsia: Safety and Efficacy in a Dog Model

    SBC: APPLIED GENETIC TECHNOLOGIES CORPORATION            Topic: N

    DESCRIPTION provided by applicant Complete achromatopsia is an autosomal recessive inherited congenital disorder of retinal cone photoreceptors Patients with complete achromatopsia experience extreme light sensitivity and daytime blindness and best visual acuity under non bright light conditions is usually or worse and generally stable over time In addition to poor acuity hypersensit ...

    STTR Phase I 2013 Department of Health and Human ServicesNational Institutes of Health
  2. A Device to Quantify Sweat of Single Sweat Glands to Diagnose Neuropathy

    SBC: Neuro Devices, Inc.            Topic: 107

    DESCRIPTION provided by applicant We devised a new generation highly sensitivity method to diagnosis peripheral neuropathy early when the probability for reversal is greatest Cancer chemotherapy and diabetes are the most common causes of neuropathy in the USA Both cause decreased sweating abnormal circulation peripheral numbness pain and weakness If diagnosed early both are potentially ...

    STTR Phase II 2013 Department of Health and Human ServicesNational Institutes of Health
  3. Acute-infarct selective cardiac MRI contrast agent

    SBC: ELGAVISH PARAMAGNETICS, INC.            Topic: NHLBI

    DESCRIPTION provided by applicant The overall goal of this project is to demonstrate the ability of our acute myocardial infarct selective paramagnetic contrast agent Gadolinium ABE DTTA to differentiate between acute and chronic infarcts in a reliable manner using contrast enhanced magnetic resonance imaging ceMRI In our Phase I data we have shown that Gd ABE DTTA exclusively highlight ...

    STTR Phase II 2010 Department of Health and Human ServicesNational Institutes of Health
  4. RF-IR Data Fusion

    SBC: Decibel Research, Inc.            Topic: MDA12T002

    The development and integration of three unique and innovative algorithm prototypes into a"Fused Track and Characterization Schema"are proposed. This Schema will encompass the determination of signatures and characteristics of objects that can be identified by RF and EO/IR Sensors in order to enable multi-sensor data fusion and correlation. The first algorithm, the"3D Pose Estimation"Algorithm, p ...

    STTR Phase I 2013 Department of DefenseMissile Defense Agency
  5. M&S Uncertainty Quantification

    SBC: OPTIMIZATION TECHNOLOGIES, INC.            Topic: MDA12T007

    OptTek Systems, Inc (OptTek), proposes an affordable, effective UQ capability for both legacy and new BMDS M & S. The OptTek Team includes research institution partner Oak Ridge National Laboratory (ORNL) and subcontractor RTSync Corporation (RTSync). The proposed BMDS M & S UQ capability maximizes insertability into existing and future MDA BMDS M & S-supported Event processes, analysis methods, a ...

    STTR Phase I 2013 Department of DefenseMissile Defense Agency
  6. M&S Uncertainty Quantification

    SBC: Numerica Corporation            Topic: MDA12T007

    A goal of Uncertainty Quantification (UQ) is to use computer simulation of complex systems to make scientifically informed assessments for high-consequence decisions. Because end-to-end empirical data is difficult to obtain for the Ballistic Missile Defense System (BMDS), computer simulation provides the best method for understanding BMDS capabilities against a wide range of threats. Numerica Co ...

    STTR Phase I 2013 Department of DefenseMissile Defense Agency
  7. Innovative Polishing Technology for Fabrication of High Performance Epi-ready GaSb Substrates

    SBC: Sinmat Inc            Topic: MDA12T003

    Antimony containing III-V semiconducting compounds are particularly attractive for the fabrication of a wide variety of electronic and optoelectronic devices such as photo detectors operating in the long wave infrared wavelength (12-32µm) range. The production of epi quality GaSb wafers still remains one of the important problems for rapid commercialization of GaSb devices. Sinmat Inc. proposes a ...

    STTR Phase I 2013 Department of DefenseMissile Defense Agency
  8. An Ultra-High Temperature Ceramic with Improved Fracture Toughness and Oxidation Resistance

    SBC: Plasma Processes, LLC            Topic: MDA09T002

    Hypersonic missile defense systems are being designed to reach global threats. During flight, external surfaces are predicted to reach temperatures in excess of 2200C. As a result, innovative, high performance thermal protection systems (TPS) are of great demand. Among ultra-high temperature ceramics (UHTC), it is well known that ZrB2- and HfB2-based materials have high melting temperatures and ...

    STTR Phase I 2010 Department of DefenseMissile Defense Agency
  9. Electro Optic Avionic Advanced Guidance, Navigation and Control (GNC) Algorithm Development to Enhance the Lethality of Interceptors Against Maneuveri

    SBC: Polaris Sensor Technologies, Inc.            Topic: MDA08T003

    This Phase II effort will further develop a technique to improve current seeker discrimination and tracking capabilities using a unique particle filter algorithm (PFA) approach. The advancement represents a significant upgrade to current and future seekers facing advanced threats in stressing environments. Quantifiable improvements over many facets of the current approach have been realized during ...

    STTR Phase II 2010 Department of DefenseMissile Defense Agency
  10. Development for Radiation Hardened Applications of Advanced Electronics Materials, Processes, and Devices

    SBC: RNET TECHNOLOGIES, INC.            Topic: MDA09T006

    The Missile Defense Agency (MDA) seeks technical investigations related to the development and application of advanced electronic materials, processes, and devices to meet its need for radiation hardened, high performance electronics for critical space and missile applications. With the advent of smaller transistor dimensions and reductions in price per bit, significant changes in materials and pr ...

    STTR Phase I 2010 Department of DefenseMissile Defense Agency
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