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Award Data
The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.
Download all SBIR.gov award data either with award abstracts (290MB)
or without award abstracts (65MB).
A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.
The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.
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Continuous measurement of cell growth as an optimal tool in drug toxicity testing (Supplement)
SBC: EnTox Sciences LLC Topic: NCATSDESCRIPTION provided by applicant During the process of screening for drugs with therapeutic potential often times several candidates emerge as prime candidates with similar efficacy and the choice for a lead compound is difficult to make However peopleandapos s lives and billions of dollars may rest on the choice of which compound to bring to clinical investigation and trials Since any lev ...
STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health -
IRE1 alpha inhibitors for Retinal Degenerative Diseases
SBC: Optikira, LLC Topic: NDESCRIPTION provided by applicant Approximately Americans suffer from vision loss due to Retinitis Pigmentosa RP Despite significant progress in elucidating the molecular genetics of RP over the past three decades no disease modifying therapies have been approved There is compelling evidence implicating endoplasmic reticulum ER stress in the pathogenesis of various forms of RP e ...
STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health -
Receptors, Ligands, and Catalysts on Demand using Expanded Genetic Alphabets
SBC: FIREBIRD BIOMOLECULAR SCIENCES LLC Topic: 100DESCRIPTION provided by applicant Technology to deliver molecules andquot on demandandquot that bind to targets or catalyze reactions of a technologistandapos s choosing would have enormous commercial value in research manufacturing and medicine Thus this has been a andquot holy grailandquot of molecular science for a half century Even today chemical theory is inadequate to support de ...
STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health -
rAAV5-hCNGB3 Gene Therapy for Achromatopsia: Safety and Efficacy in a Dog Model
SBC: APPLIED GENETIC TECHNOLOGIES CORPORATION Topic: NDESCRIPTION provided by applicant Complete achromatopsia is an autosomal recessive inherited congenital disorder of retinal cone photoreceptors Patients with complete achromatopsia experience extreme light sensitivity and daytime blindness and best visual acuity under non bright light conditions is usually or worse and generally stable over time In addition to poor acuity hypersensit ...
STTR Phase I 2013 Department of Health and Human ServicesNational Institutes of Health -
Identifying activators of interferon regulatory factors for neuroprotection
SBC: Neuralexo, LLC Topic: NINDSDESCRIPTION provided by applicant Stroke is a leading cause of morbidity and mortality in the United States However less than of patients are eligible for the current approved interventions of tissue plasminogen activator or thrombectomy We seek to develop new therapeutics to reduce the extent of damage and functional impairment resulting from ischemic injury to the brain an area of signi ...
STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health -
Custom Fit 3D-Printed Pediatric Respiratory Masks
SBC: ADVANCED MEDICAL ELECTRONICS CORP Topic: NICHDDESCRIPTION provided by applicant This project will develop an FDA approved process D printing system and advanced D printable material suitable for point of care manufacturing of custom fit continuous positive airway pressure CPAP masks for neonates In extremely low birth weight infants nasal CPAP therapy is delivered via soft biocompatible neonatal sized nasal masks suitable for lon ...
STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health -
Scientific Merit and Feasibility of Fructokinase Inhibiton for Obesity
SBC: COLORADO RESEARCH PARTNERS LLC Topic: NIDDKDESCRIPTION provided by applicant Intake of added sweeteners high fructose corn syrup and sucrose independently predicts the development of obesity metabolic syndrome and diabetes Despite recommendations by WHO and the AHA to reduce sugar intake to to percent of total energy intake the mean intake of added sugars remains percent of the diet and percent of the population ingest ...
STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health -
IRE1 alpha inhibitors for type 2 diabetes
SBC: Optikira, LLC Topic: 200DESCRIPTION provided by applicant The American Diabetes Association has declared type diabetes T D a public health crisis T D begins as a state of compensated insulin resistance frank disease develops when of insulin producing pancreatic islet cells of affected individuals undergo cell death Endoplasmic reticulum ER stress has emerged as a central underlying mechanism that drive ...
STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health -
A screening assay for chemicals that affect the differentiation of human neural cells.
SBC: NZUMBE INC Topic: NIEHSDESCRIPTION provided by applicant Human brain development represents a highly vulnerable time to chemical exposures because immature cells are actively undergoing differentiation into more complex cell types e g neurons astrocytes oligodendroglia to form neural circuits A major reason for this vulnerability is that neuronal differentiation requires critical time dependent changes to the ...
STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health -
Smartphone Technology for Parents and Teens: Improving Vaccination Uptake
SBC: KLEIN BUENDEL, INC. Topic: NICHDDESCRIPTION provided by applicant Vaccinations for adolescents in the U S tetanus diphtheria and acellular pertussis Tdap meningococcal conjugate vaccine MCV Human Papillomavirus HPV vaccines Gardasil and Cervarex remain well below the Centers for Disease Control and Prevention CDC goals and especially so for the HPV vaccines These vaccine deficits are pronounced among minor ...
STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health