Award Data

There are currently no vaccines or therapeutics available for Marburg Virus Disease (MVD). Given the specter of weaponization and the terriblemorbidity and high mortality rate of MVD, this represents a critical threat to the operational readiness of the Warfighter. While traditionalvaccines have proven to be a huge contribution to public health, they do have some limitations especially in the cont ...

Universal Technology Corporation (UTC) has teamed with the University of Dayton Research Institute (UDRI), Stratonics, and Macy Consulting to demonstrate not only the transitionability into commercial systems, but also to develop the data analytics and monitoring and control requirements to extract the full value fromseveral sensors, including the Stratonics ThermaViz, acoustic and profilometry se ...

Flow Pharma, Inc. is a biotechnology company in the San Francisco Bay Area developing fully synthetic cytotoxic T lymphocyte (CTL)stimulating peptide vaccines for Marburg virus. The FlowVax vaccine platform allows us to create dry powder formulations of biodegradablemicrospheres and TLR adjuvants incorporating class I and class II T cell epitopes. FlowVax vaccines can be designed for delivery by i ...

In resource limited settings, rapid and accurate diagnosis of infections is critical for managing potential exposures to highly virulent pathogens,whether occurring from an act of bioterrorism or a natural event. This is especially important for hard to detect intracellular bacterial andalphavirus infections, that overlap symptomatically and often treated empirically due to a lack of reliable and ...

The objective of this proposal is to examine the feasibility of defining and measuring key dimensions of an urban system to include its essential functions and networks, and whether they can be modelled in a computational framework for assessing robustness and resilience of DUTs (and their tipping points) under conditions of volatility and stress. This proposal will conduct a comprehensive review ...

CONCUR develops a computational framework for assessing and characterizing urban environments stability or fragility in response to volatility and stress, identifying specific weaknesses as well as key tipping points which could lead to rapid systemic failure. CONCUR explicitly models urban environments as emergent complex systems, focusing attention on the critical triggers that could lead to rap ...

Metallic additive manufacturing (AM) is an attractive technology for the production of lethality test articles due to the potential for significantly reduced lead time and manufacturing cost.However, in order to be effective in providing accurate lethality data, the properties of the AM material have to match closely the properties of conventionally manufactured alloys found in real threat targets ...

The Department of Defense uses large-scale high-resolution federated simulations to propagate rocket vehicle trajectories. Runge-Kutta methods have served as a de-facto standard while conducting such simulations. However, there are several challenges while using Runge-Kutta methods for this task. Firstly, there should be exact time-step matching between federates, otherwise the states have to be i ...

West Coast Solutions (WCS), in collaboration with the Georgia Institute of Technology and Creare LLC, proposes an adaptation of our SmallSat Stirling Cryocooler (SSC) technology in response to STTR Topic MDA17-T003: High-Efficiency, Low-Volume, Space-Qualified Cryogenic-Coolers. In Phase 1 we will scale up a design currently in development for NASA to meet the Missile Defense Agency (MDA) topic re ...

The Iris Technology team which also include Northrop Grumman Aerospace Systems (NGAS) and the University of Wisconsin, is attacking the problem of high-efficiency, low-volume, space-qualified cryocooler systems.The team has a firm starting point by leveraging the Northrop Grumman Microcryocooler and the Iris Technology mLCCE (Miniature Low Cost Control Electronics).TMU enhancement will start with ...