Award Data

DESCRIPTION (provided by applicant): Cancer treatment today is in need of tumor-specific and effective therapies that do not harm the patient and thereby compromise treatment efficacy and prolong recovery time. A multi-modal therapeutic and imaging agent t hat does not damage healthy living tissue would have tremendous benefit to researchers and victims of this deadly disease. Nanomaterials have t ...

DESCRIPTION (provided by applicant): This project will support research and further development of a novel commercializable product designed to reduce and mitigate the psychological impact of a major disaster. The long-term objective of this project is to provide a scientifically supported, highly accessible, culturally relevant, anonymous multi- media system that fills the current gap in mental ...

DESCRIPTION (provided by applicant): Over five hundred years of contact with European culture has had a profound impact on American Indian communities, with destructive policies implemented in the service of assimilation efforts that broke up the extended family and community. The strains of history pressing on American Indian families are reflected in research indicating weakened family connecti ...

DESCRIPTION (provided by applicant): Prior descriptive research has examined family involvement in residential long-term care, and a handful of nursing and psychosocial interventions have attempted to facilitate family involvement and residents' social int egration in nursing homes. However, the intensity and potential intrusiveness of these interventions may make them difficult to administer as r ...

DESCRIPTION (provided by applicant): Among the most undesirable sequelae of chemo- and radiotherapies for the treatment of cancer are bone marrow hypoplasia and pancytopenia. These can further lead to immunodeficiency, bleeding and hypoxia significantly i mpacting the morbidity of cancer patients. The discovery of growth factors that regulate hematopoietic stem cells (HSC) proliferation led to th ...

DESCRIPTION (provided by applicant): Human umbilical cord blood is a rich source of hematopoietic stem cells that can be used to re-populate the blood and immune systems. In preliminary studies we have identified a novel population of non-hematopoietic cel ls that exhibit extensive self-renewal and markers characteristic of stem cells. We postulate that these cells can be used to repair the brain ...

DESCRIPTION (provided by applicant): This Phase I STTR is focused on testing the feasibility of developing a scalable, commercial health information system based on ClinfoTracker, an existing system developed in an academic setting. The proposed system can significantly impact the recognition, tracking and management of chronic diseases such as cancers. By tracking and managing activities and out ...

DESCRIPTION (provided by applicant): Recent studies indicate that the prevalence of overweight and obesity in children is very high (about 25-30 percent), and the incidence is increasing, especially among minority African- American and Hispanic children. O besity in childhood is associated with a high risk of continued obesity into adolescence and adulthood. This is of great public health signific ...

DESCRIPTION (provided by applicant): The overall goal of Discovery Genomics, Inc. is to develop the Sleeping Beauty transposon system for human gene therapy. To achieve this to treat hemophilia, we must be able to direct uptake and long-term expression of therapeutic genes in targeted tissues such as the liver. Only one method of plasmid delivery has been effective for high-level gene expression ...

DESCRIPTION (provided by applicant): Close to 40% of US children are exposed to secondhand tobacco smoke (SHS) in homes and up to 50% in cars, compromising the health and lives of millions of children. More effective, inexpensive, and accessible interventi ons are needed that impact parents' and caregivers' willingness and ability to institute smoking restrictions. We propose the development of an ...