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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Regenerative Therapy for Corneal Endothelial Dystrophies and Injuries

    SBC: RASHMIVU LLC            Topic: N

    Summary Worldwide, only 1 out of 70 patients with corneal endothelial dystrophies and injuries receive a corneal transplant due to the limited corneal donor pool, the need for advanced surgical facilities and talent, and expense. RashmiVu is developing a stem cell based regenerative technology that addresses this large unmet global need through a paradigm shift, wherein treatment could be as simpl ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  2. Photo-mediated ultrasound therapy for treatment of cutaneous vascular malformations

    SBC: PHOTOSONOX LLC            Topic: NIBIB

    ABSTRACT: Cutaneous vascular malformations (CVM), such as port wine stain (PWS) which occurs in 0.3–0.5% of newborns, are often a cause of great concern to patients for both medical and cosmetic reasons. Laser irradiation with flashlamp-pumped pulsed dye lasers, i.e. photothermolysis therapy (PTT), is currently the gold standard treatment for PWS. Most patients with PWS, however, fail to clear c ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  3. Development of a topical fixed-dose combination drug for peripheral neuropathic pain.

    SBC: WinSanTor, Inc.            Topic: NINDS

    PROJECT SUMMARY An estimated 30 million people in the United States suffer from some form of peripheral neuropathy, a condition that develops as a result of damage to the peripheral nervous system. The top two major causes of peripheral neuropathy in the US are diabetes mellitus (both T1DM and T2DM) and chemotherapeutic agents. Currently, there are no FDA-approved treatments to prevent or reverse ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  4. Lead compound discovery from proprietary mycobacterial strains for treatment of PTSD

    SBC: MYCOBACTERIA THERAPEUTICS CORPORATION            Topic: NCCIH

    Project Summary Immunoregulation, i.e., balanced expression of regulatory and effector T cells, is thought to be compromised in modern high-income settings due in part to reduced contact with commensal and environmentally derived bacteria, also known as “old friends”. Failed immunoregulation is thought to be one factor contributing to recent increases in stress-related and chronic inflammatory ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  5. Development of an irreversible covalent inhibitor of FMS-like tyrosine kinase receptor 3 for treating acute myeloid leukemia

    SBC: BRIDGENE BIOSCIENCES INC            Topic: 102

    PROJECT SUMMARY Acute myeloid leukemia (AML), a malignant disease of hematopoietic precursor cells in the bone marrow, is one of the most common cancers in adults accounting for 1% of all cancers. AML is typically diagnosed later in life with individuals 60 and older having a long-term survival rate of merely 5-15%. Cytogenic analysis of the abnormal cells at the time of diagnosis has proven to be ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  6. FES-Rowing: Preventing the Secondary Conditions of Paralysis Through Vigorous Exercise

    SBC: Myolyn, LLC            Topic: NICHD

    PROJECT SUMMARY/ABSTRACT Lack of exercise is a major cause of secondary health conditions, especially for people with paralysis, for whom participation in physical activity is especially difficult. Hybrid functional electrical stimulation (H- FES) exercise enables vigorous, total body physical activity for people with paralysis. However, existing H-FES devices are neither affordable nor accessible ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  7. STING Activators as Therapy for Cancer

    SBC: STINGINN, LLC            Topic: 101

    PROJECT SUMMARY The ability of dying cells to activate antigen presenting cells (APCs) is carefully controlled to avoid unwarranted inflammatory responses. Thus, tumor cells avoid aggravating APCs by efficiently simulating regular dying cells which following phagocytosis do not trigger inflammatory responses required for efficient cytotoxic T lymphocyte (CTL) priming. However, dying tumor cells co ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  8. Contamination resistant interconnection for reducing peritoneal dialysis- associated peritonitis

    SBC: CEROVATIONS LLC            Topic: 400

    Abstract Significance: Peritonitis remains a significant challenge in the management of end stage renal disease (ESRD) for patients on peritoneal dialysis (PD) and contributes significantly to morbidity and mortality. More than half of these infections result from bacteria originating on skin or mucous membranes, suggesting patient or caregiver contamination as the source of infections. Furthermor ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  9. A novel non-invasive method of aspiration detection in preterm infants.

    SBC: NUBORN MEDICAL INC            Topic: NICHD

    PROJECT SUMMARY/ABSTRACT Ten percent of the approximately four million infants born in the United States each year are born premature (andlt;37 weeks gestational age). Preterm birth prior to the maturation of critical neonatal body systems results in prolonged hospitalizations that impose an annual societal cost burden of $26 billion. Achievement of the ability to fully orally feed is often the la ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  10. Eliminating the human factor from stereotaxic surgeries

    SBC: POPNEURON LLC            Topic: 104

    Project Summary: The main goal of this research project is to develop a new line of new stereotaxic devices for small animal research that outperforms existing devices in terms of accuracy, reproducibility, and ease of use. Advancing a tool such as an electrode, injection pipette or optical fiber through a small hole in the cranium, sometimes over long distances, and placing it precisely in a part ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
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