Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until June, 2020.

  1. A CD8+ T cell diagnostic to identify children with pulmonary tuberculosis

    SBC: ViTi, Inc            Topic: NIAID

    DESCRIPTION provided by applicant Tuberculosis TB disease which results from infection with Mycobacterium tuberculosis Mtb is a leading cause of infectious morbidity and mortality in children andlt years old worldwide In TB endemic regions in which the vast majority of the worldandapos s annual million adult cases of TB disease reside children andlt years old account for ...

    SBIR Phase II 2013 Department of Health and Human ServicesNational Institutes of Health
  2. A rapid and high-throughput microfluidic stem cell analyzer

    SBC: CFD Research Corporation            Topic: OSD11H14

    Current methods to discern the differentiation state of stem cells are time-consuming, labor-intensive, costly, invasive, and consequently, ill-suited for clinical applications. To overcome these limitations, we propose to develop a microfluidic stem cell analyzer for accurate, non-invasive identification of the cell differentiation state in conjunction with automated cell sorting at high-throughp ...

    SBIR Phase II 2013 Department of DefenseDefense Health Program
  3. A research and drug development tool for the real time in vitro study of single c

    SBC: KYTARO, INC.            Topic: 100

    DESCRIPTION In this SBIR Phase II PicoCal will develop a high throughput apparatus to measure changes in cell adhesion at the level of individual receptor ligand interactions in real time This tool finds critical applications in research and drug development and would allow researchers to study and manipulate adhesion by bioactive compounds to promote or inhibit physiological processes There is a ...

    SBIR Phase II 2013 Department of Health and Human ServicesNational Institutes of Health
  4. Accelerating Site-specific Characterization of Protein Therapeutics with Novel Machine Learning Methods

    SBC: MASSMATRIX, INC.            Topic: 400

    PROJECT SUMMARYABSTRACT TitleAccelerating Site specific Characterization of Protein Therapeutics with Novel Machine Learning Methods The project seeks to improve reliability and speed up the development of life saving and life enhancingprecisionprotein therapeutics and magnify the positive impact of biomedical research and education worldwideleading to a quantum leap in our understanding of the mo ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  5. A compact, modular two-photon fiber-coupled microscope for in vivo all-optical electrophysiology

    SBC: INTELLIGENT IMAGING INNOVATIONS, INC.            Topic: 101

    Good methods to interrogateand ideally perturbneural systems at the network level have been elusive until recentlyThe advent of biochemical breakthroughsnamely neuronally targeted genetically encoded calcium reporterssuch as GCaMPand light activated channelssuch as channelrhodopsinhave enabledall opticalelectrophysiology where experiments can be conducted that involve simultaneousor closely sequen ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  6. A computational platform to improve the prioritization of drugs and target genes for therapeutic intervention

    SBC: Genetic Networks, LLC            Topic: 100

    Project Summary This project proposes further development of a computational discovery platform shown to quantifiably identify and prioritize both targets and compounds for therapeutic interventionwhich will accelerate the development of newermore effective drugs with fewer side effectsThis platform is based on a novel fusion of two state of the art computational approachesphenolog mapping and fun ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  7. Acute-infarct selective cardiac MRI contrast agent

    SBC: ELGAVISH PARAMAGNETICS, INC.            Topic: NHLBI

    DESCRIPTION provided by applicant The overall goal of this project is to demonstrate the ability of our acute myocardial infarct selective paramagnetic contrast agent Gadolinium ABE DTTA to differentiate between acute and chronic infarcts in a reliable manner using contrast enhanced magnetic resonance imaging ceMRI In our Phase I data we have shown that Gd ABE DTTA exclusively highlight ...

    STTR Phase II 2010 Department of Health and Human ServicesNational Institutes of Health
  8. A Dried Blood Spot Companion Diagnostic to Measure Neuroendocrine Changes in ADHD.

    SBC: ZRT LABORATORY, LLC            Topic: NCCIH

    REVISED ABSTRACT Attention Deficit Hyperactivity DisorderADHDis a common neurodevelopmental disorder marked by inattentionhyperactivity and impulsivityStimulant therapies can be effective for alleviating ADHD symptomshoweverdue to neurobiological heterogeneity of ADHDsome patients are non respondersor develop undesirable side effectsThis creates a process of trial and error in the clinical pursuit ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  9. Advance Care Planning in the Dementias: Culturally-Tailored Caregiver Education for African Americans

    SBC: Collinge And Associates, Inc.            Topic: N

    African Americans face significantly greater risk of Alzheimer s Disease and other dementias than white Americans but receive disproportionately less attention to dementia screening and supportresulting in a silent epidemic in this underserved populationAdvance Care Treatment PlanACT Planis a culturally tailored caregiver education program for African American dementia caregivers with decisional r ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  10. Advanced CLAD PERG system with minimal patient preparation for clinical settings

    SBC: JORVEC CORP.            Topic: N

    AbstractGlaucoma is one of a number of optic nerve diseases which lead to retinal ganglion cellsRGCdegenerationultimately manifesting in a functional loss of vision if left untreatedThere exist a number of therapeutic approaches to treat these conditionsbut there are currently no clinical methods to detect the onset of RGC dysfunctionThe Pattern ElectroretinogramPERGis the only established tool to ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
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