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The Award database is continually updated throughout the year. As a result, data for FY22 is not expected to be complete until September, 2023.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

  1. 3D Printed Multifunctional Brain Windows for Simultaneous Optical Imaging and Electrophysiology

    SBC: Applied Universal Dynamics, Corp.            Topic: 107

    PROJECT SUMMARY This proposal responds to PAR-18-870 titled “BRAIN Initiative: Development Optimization, and Validation of Novel Tools and Technologies for Neuroscience Research (STTR).” This project is a Fast Track STTR with a phase I and phase II. The small business, Applied Universal Dynamics Corp. (AUD) is collaborating with the University of Minnesota (U of MN). The activity patterns of t ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  2. A SAFE AND COMPACT NEONATE TO ADULT NEUROIMAGING MRI SYSTEM

    SBC: ADVANCED IMAGING RESEARCH, INC.            Topic: 101

    NIH SBIR PA-18-871 w/o Clinical Trials A Safe and Compact Neonate to Adult Neuroimaging MRI System The intriguing human brain is the most imaged end-organ non-invasively, without ionizing radiation using magnetic resonance imaging (MRI). High spatial resolution brain MRI is an established diagnostic tool to assess injury mechanisms affecting newborn growth and the adult human connectome. To predic ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  3. An Automated System to Locate Items Misplaced by Persons with Dementia in a Care Facility

    SBC: Applied Universal Dynamics, Corp.            Topic: NIA

    Abstract This application responds directly to the purpose of the PAR-18-588 SBIR Funding Opportunity Announcement (FOA). This project will develop an assistive system for caregivers of persons with dementia (PWD) to locate items that have been misplaced by PWD. A PWD who misplaces objects can create feelings of anxiety and frustration for both the PWD and the caregivers. The PWD can leave an obje ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  4. Pharmacologic Suppression of Reperfusion Injury Following Endovascular Thrombectomy In Stroke.

    SBC: BIOMIMETIX JV LLC            Topic: 102

    Ischemic stroke is a leading cause of death and disability in the United States. This often is attributable to thrombus formation at an atherosclerotic plaque or thromboembolism. Patients who present within 4.5 hours of symptom onset are eligible for thrombolysis with tissue plasminogen activator (tPA). This serves andlt;5% of victims. Recently, major advance has been made with proven efficacy fro ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  5. Extending WAAVES+: An animal and environment-agnostic, automated USV scoring platform for high-throughput social, behavioral, and neuropharmacological studies

    SBC: CORNERSTONE RESEARCH GROUP INC            Topic: 101

    Project SummaryUltrasonic vocalizations (USVs) are known to reflect emotional processing, brain neurochemistry and brain function - key observations in animal model studies. Collecting and processing USV data is time-intensive, manual, and costly. Most importantly, it limits researchers’ ability to employ fully effective, and nuanced experimental designs, and is a barrier to entry for other rese ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  6. Novel drugs combinations for improving survival from Acute Radiation Syndrome when administered 48h postirradiation

    SBC: BOLDER BIOTECHNOLOGY INC            Topic: R

    Abstract. Bone marrow is one of the most radiation-sensitive tissues, and patients acutely exposed to total body irradiation (TBI) doses andgt; 2 Gy develop severe neutropenia, thrombocytopenia, anemia, and lymphopenia within days to weeks of exposure, often dying from infections (due to a lack of neutrophils) and uncontrolled bleeding (insufficient platelets) (referred to as the hematopoietic acu ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  7. A single dose long-acting non-addictive polymer conjugate formulation of buprenorphine that provides immediate and prolonged analgesia for post-operative pain

    SBC: SERINA THERAPEUTICS INC            Topic: NINDS

    PAProject Summary Abstract SERis a long acting polymer pro drug of buprenorphine that is being developed to treat postoperative pain following major surgeries such as bunionectomyabdominoplastythoracotomy and knee and hip surgerySERhas no biological activity by itselfbut when administered in vivo by subcutaneous injection it enters the vascular compartment where a plasma esterasebutyrylcholinester ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  8. Cerebral Spinal Fluid Shunt System with Dual Lumen Distal Catheter Redundancy to Minimize Revision Surgery

    SBC: Cerovations, LLC            Topic: 102

    Abstract Significance: Cerebral spinal fluid (CSF) shunt failure resulting in revision surgery is a major problem for hydrocephalus patients. Up to 50% of shunts fail within two years of implant. A NIH funded expert panel has identified improved shunt design as a research priority to improve hydrocephalic patient outcomes. Occlusion is the most common CSF shunt failure mode, and little has changed ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  9. Ultra-Fast Combinatorial Analysis for Biomarker Discovery

    SBC: ROCKETML INC            Topic: 400

    Project Summary Abstract SignificanceOne of healthcare s largest challenges is that many patients do not respond to treatmentBy recent estimatesaroundof drugs are effective for less thanof patientsThis causes enormous physicalsocialand economic sufferingThe annual cost of ineffective treatment is estimated at $billion per year in the US aloneMoreovervariable treatment response contributes to the r ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  10. Targeting Latexin for radiation mitigation.

    SBC: P2D, INC            Topic: NIAID

    The purpose of this grant is to develop novel therapeutic approaches for radiological/nuclear medical countermeasures. Very few medical products have been shown to counter the acute and long-term injuries that can result from a nuclear or radiological accident or attack. Medical products and regimens that mitigate and/or treat radiation injury post-exposure (i.e., administration of first dose to s ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
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