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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Improving adherence to evidence-based practice using an innovative and easy-to-use health IT solution

    SBC: ADHERE.LY, LLC            Topic: 104

    PROJECT SUMMARY/ABSTRACT Homework, or between-session practice of skills learned during therapy, is one of the most integral, yet underutilized components of high-quality, evidence-based mental health treatments (EBTs) such as Cognitive Behavioral Therapy (CBT). Many providers struggle to consistently develop, assign, and assess homework exercises with their patients, and many patients have diffic ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  2. Portable hand-held proprietary xenon inhaler for rapid reduction of opioid withdrawal symptoms

    SBC: NOBILIS THERAPEUTICS, INC.            Topic: NIDA

    Summary/Abstract People with opioid use disorder (OUD) experience aversive opioid withdrawal symptoms (OWS) including nausea, diarrhea, vomiting, and anxiety, which emerge when blood opioid levels wane. These symptoms perpetuate unprescribed opioid use and accompanying morbidity and mortality, costing society nearly $80 billion per year. Withdrawal symptoms also emerge upon initiation of OUD pharm ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  3. I-Corps Project plan for:STTR Phase I Development of therapeutics to treat fentanyl overdose using a validated animal model

    SBC: TORRALVA MEDICAL THERAPUETICS LLC            Topic: NIDA

    Project Summary According to the Centers for Disease Control (CDC), synthetic opioids are currently the most common cause of overdose death in the U.S, while heroin and prescription opioid deaths have decreased significantly since 2017. Despite the widespread availability of naloxone, deaths from fentanyl and fentanyl analogues (F/FA) continue to rise in parallel with increasing reports of F/FA re ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  4. Protection of donor kidneys with synchronization modulation electric field (SMEF)

    SBC: WR Biotech, LLC            Topic: 400

    The objective of this proposal is to examine a novel technique called improved Synchronization Modulation Electric Field (i-SMEF) in protection of donor kidneys and improvement of transplanted graft functions. We will apply the i-SMEF on donor kidneys during cold storage and evaluate the transplanted graft function following kidney transplantation in mice.We have developed a novel technique, named ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  5. A two-dimensional antiscatter grid for dental cone beam computed tomography

    SBC: M2 Technologies LLC            Topic: NIDCR

    Project summary Cone beam computed tomography (CBCT) is a commonly used 3D x-ray imaging modality in dental and craniofacial imaging. While CBCT is primarily employed in evaluating bony anatomy in 3D, soft tissues are often poorly visualized in dental CBCT images. Moreover, tissue densities cannot be extracted accurately from CBCT images. The main culprit behind this problem is scattered radiation ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  6. A Peptide-Based Polyplex Platform for Nucleotides Delivery to the Sites of Inflammation

    SBC: Trasir Therapeutics, Inc.            Topic: 100

    AbstractRNA interference (RNAi) is an evolutionary conserved mechanism for post transcriptional control of protein expression in which short double-stranded RNA target specific messenger RNA (mRNA) for degradation, thus inhibiting protein translation. siRNA has great potential to revolutionize medicine by enabling highly specific and efficient silencing of proteins involved in disease pathogenesis ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  7. 3D Printed Multifunctional Brain Windows for Simultaneous Optical Imaging and Electrophysiology

    SBC: Applied Universal Dynamics, Corp.            Topic: 107

    PROJECT SUMMARY This proposal responds to PAR-18-870 titled “BRAIN Initiative: Development Optimization, and Validation of Novel Tools and Technologies for Neuroscience Research (STTR).” This project is a Fast Track STTR with a phase I and phase II. The small business, Applied Universal Dynamics Corp. (AUD) is collaborating with the University of Minnesota (U of MN). The activity patterns of t ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  8. Enabling rapid and effective stroke thrombectomy procedures from a Transradial approach:Combining introducer sheath, guide catheter, and distal access catheter into a single device.

    SBC: CONWAY MEDICAL LLC            Topic: 105

    PROJECT SUMMARY/ABSTRACT This proposal’s long-term goal is to improve the care of patients suffering from Large Vessel Occlusion Acute Ischemic stroke (LVO AIS). Emergent, catheter-based thrombectomy is an established treatment for LVO AIS. Still, substantial limitations remain. Rapid catheterization of distal, intracranial vessels represents an essential feature of successful thrombectomy proce ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  9. Use of polymer-peptide system to deliver cells for intervertebral disc regeneration

    SBC: BioRestorative Therapies, Inc.            Topic: NIAMS

    Abstract Low back pain affects millions of Americans and causes $100 billion socioeconomic loss annually. One of the prominent risk factors is intervertebral disc degeneration. Current treatments are palliative for relieving pain without restoring disc biology or biomechanics. Pain recurrence is common. Spinal fusion is popular, but it is limited by high failure rate (up to 30%) while predisposes ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  10. Development of a new drug for treating autoimmune uveitis

    SBC: ABCON THERAPEUTICS, INC.            Topic: NEI

    SummaryAutoimmune uveitis is a major cause of blindness in which retinal antigen-specific T cells lead to ocular inflammation and vision loss. Similar to the treatment of other T cell-mediated autoimmune diseases, selective suppression of the pathogenic T cells is the “holy grail” of therapeutic development. In pilot studies, we have developed a novel antibody-drug conjugate (ADC) with combine ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
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