Award Data

The twenty-first century has seen a global rise in bacterial infections exhibiting antimicrobial-resistance (AMR). More than ninety percent of chronic wounds contain microbial biofilms that exhibit AMR, and the bacteria responsible for several of these recalcitrant infections are called ESKAPEE pathogens. Eradicating ESKAPEE pathogenic infections is challenging, but bacteriophage (phage) therapy i ...

Multi-drug resistant (MDR) bacterial infections are a global public health crisis with ESKAPEE (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter spp, and Escherichia coli.) pathogens particularly troublesome. Wound infection is usually acquired in the hospital setting and is a significant source of morbidity and morta ...

Realistic surgical simulation requires a combination of representative tissue geometry, accurate tissue material properties and lifelike tool-tissue interaction forces. Recent advances in computational power and imaging modalities have provided the capability to represent the anatomical details required for surgical training; however, the mathematical models which govern the underlying tissue pro ...

BioMojo LLC and the Departments of Mathematics and Biomedical Engineering at the University of North Carolina Chapel Hill, will develop a preliminary bio mathematical model framework to represent how human tissues interact and behave at their boundaries. Tissue interaction properties (e.g. tensile, shear, friction, and so forth) of connective, epithelial, muscular, and nervous tissue including su ...

Most standard-of-care tools and techniques for evaluating neck disorders are subjective, unreliable, and do not provide actionable information for providers, payers, and organizations to deliver efficient and effective care. This lack of objective neck he

In emergency medicine, time is a critical factor that can significantly influence the survival of seriously ill patients. Early recognition of clinical deterioration and rapid initial management is paramount in any setting where emergency care is provided. In military medicine and humanitarian care, delivering high quality and timely care to injured patients poses even greater and more complex cha ...

Early recognition of impending decompensation and appropriate intervention is critical to patient survival in many situations; yet, military personnel receive limited training about the early signs of decompensation through established training courses. Descriptions of respiratory distress, shock, and poor perfusion may be offered in training, but with little opportunity to practice recognizing th ...

Surgical simulations aiming to support surgeon practices and medical education have attracted enormous research effort over the last two decades. However, the physical reality, especially on simulating aggregated tissue interaction, is still unsatisfactory. In this proposed work, an open source surgery simulation framework, SoFMIS, will be utilized and enhanced with tissue interaction models to a ...

According to the Department of Defense, there were more than 400,000 known TBI diagnoses in service members between 2000 and 2019 (DVBIC, 2020). Detection and measurement of potential injury due to blast overpressure and blunt impact have been priorities of the US military for many years, especially since Operation Enduring Freedom (OEF). Among those deployed, estimated rates of probable TBI range ...

Defense Health Agency (DHA) is seeking a multi-functional diagnostic to determine blood coagulopathy in real time at point-of-care (POC). Blood coagulopathy, resulting in uncontrolled bleeding, is implicated in 80% of operating room deaths and 50% of trau