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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. THIS SBIR PHASE I CONTRACT IS FOR A WEARABLE ALCOHOL BIOSENSOR THAT QUANTIFIES BAC IN REAL TIME.

    SBC: DeLeon, Augustina S            Topic: NIAAA

    Technology validation study of a wearable NIR spectrometer to quantify BAC in real time

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  2. Electrochemical aptasensor for Anti-Tuberculosis antibiotic quantification

    SBC: Guild Associates, Inc.            Topic: NIAID

    Specific AimsIn Phase I of this SBIRwe will complete three specific aimssynthesize stable combination adjuvant formulations that are compatible with an HVLP antigenidentify the combination adjuvant properties that augment the safe and durable immunity to Handdemonstrate the superior protective benefit of the new combination adjuvant over existing adjuvant solutions for pandemic influenza vaccinesI ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  3. TOPIC 386: NOVEL ORALLY BIOAVAILABLE PDE-CATENIN INHIBITOR CONCENTRATES IN LUNG FOR CANCER CHEMOPREVENTION

    SBC: ADT Pharmaceuticals, LLC            Topic: NCI

    This application is based on ADT Pharmaceuticalsdiscoveries thatthe cGMP degrading phosphodiesterase isozymephosphodiesteraseAPDEis overexpressed during early stages of tumorigenesisgenetic knockdown of PDEresults in selective apoptosis of tumor cells by activating cGMP PKG signalingandsmall molecule inhibitors of PDEinduce apoptosis by PKG phosphorylation of oncogeniccateninthereby suppressing Tc ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  4. TOPIC 396- IMAGING FOR CANCER IMMUNOTHERAPIES-MOONSHOT

    SBC: COLUMBUS NANOWORKS, INC.            Topic: NCI

    In vivo imaging of cells labeled with fluorescent nanodiamondsFNDsis a new way of monitoring immune cells during cancer immunotherapyFNDs are non toxicinfinitely photostable nanomaterials that are easily conjugated with antibodiesand emit fluorescence in the near infrared spectral regionIn this Phase I SBIRwe will use a murine melanoma model and outline a plan to use FNDs for imaging immunosupress ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  5. TOPIC 389- INTELLIGENT SOFTWARE FOR RADIATION THERAPY PLANNING

    SBC: RadiaSoft LLC            Topic: NCI

    Besides surgeryradiotherapy is the most effective treatment modality for localized prostate cancerThe success of radiotherapy stems from the exploit of a therapeutic window in tumor response and normal tissue tolerance which maximizes the chance of sterilizing the tumor while sparing the surrounding normal tissue from severe damageThis requires an accurate and individualized radiation dose distrib ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  6. Strong protections, tracking, diversion detection, and deactivation of opioid medications in the hospital and related caregiving settings.

    SBC: Curazel LLC            Topic: NIDA

    Under the Small Business Innovation Research ProgramSBIRPhase I programTopicthe Contractor will develop a comprehensive approach to allow hospitals gain control of their opioid medicationsThe Contractor approach is totrack opioids from the pharmacy to the patienttrack the amount given to the patientand for opioid waste to track it back to the pharmacybetter administer opioids to patients that offe ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  7. STING Inhibitor Discovery for Rare and Common Autoimmune Diseases

    SBC: DISCOVERYBIOMED, INC.            Topic: NIAID

    Principal Investigators for Small BusinessDiscoveryBioMedIncDBMand Nitor TherapeuticsIncNitorProject Summary Abstract The over arching commercial goal for this Nitor TherapeuticsIncNitorand DiscoveryBioMedIncDBMcollaboration is to discover and validate Stimulator of Interferon Genes orSTINGinhibitor ligands in a novel high throughput screeningHTSand validation based Critical Path of bioassaysAberr ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  8. Rodents Derived Synthetic Blood Brain Barrier Models for Chemical Toxicity Screening

    SBC: CFD Research Corporation            Topic: NIEHS

    AbstractThe overall goal of this study is to develop and demonstrate a novelpredictive in vitro organotypicD culture models of the blood brain barrierBBBderived from rodents for chemical toxicity screeningIn contrast with current Transwell based static and microfluidic assaysour commercially available SynBBB model enables real time visualization and quantitation of transport permeation under physi ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  9. Screening Device for Autism Spectrum Disorders using High Stimulation Rate ABR with Continuous Loop Averaging Deconvolution

    SBC: Intelligent Hearing Systems Corp.            Topic: NIDCD

    The purpose of this proposal is to develop an automated Auditory Brainstem ResponseABRbased neurological screening device and software module that will enhance the early detection of autism and other neurological conditionsAutism Spectrum DisordersASDhave an incidence rate ofBased onmillion births in the United States innew cases of ASD will be diagnosed from that birth cohort aloneThe practice of ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  10. Bioinformatic Tools for Interpretation of Glycan Array Data

    SBC: Z Biotech, LLC            Topic: 400

    Project SummaryAbstract There is an urgent need of bioinformatic tools for mining glycan array data in order to accurately and statistically study the interactions between cell surface glycans and glycan binding proteinsWe propose here to develop a software and hardware integrated system for the interpretation of glycan array dataThe problem with existing glycan array data mining tools is that the ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
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