Award Data

DESCRIPTION (provided by applicant): Osteoarthritis (OA) is the leading cause of chronic disability in the United States. A clinical goal in the treatment and prevention of OA is to develop replacement cartilage using tissue engineering (TE) technologies. Although TE cartilage presently lacks the mechanical stability of native cartilage, studies have demonstrated that mechanical stability can be e ...

Niobium alloy (C-103) reaction control system (RCS) chambers have been used on numerous NASA programs. However at elevated temperatures, the strength of C-103 decreases significantly. Higher strength niobium alloys have been developed, but these alloys lack the formability of C-103. Recently, Additive Manufacture (AM) of niobium and C-103 has been demonstrated using powder bed electron beam me ...

Universal Technology Corporation (UTC) has teamed with the University of Dayton Research Institute (UDRI), Stratonics, and Macy Consulting to demonstrate not only the transitionability into commercial systems, but also to develop the data analytics and monitoring and control requirements to extract the full value fromseveral sensors, including the Stratonics ThermaViz, acoustic and profilometry se ...

Project Summary Traumatic brain injuryTBIcauses detrimental behavioral dysfunctions and brain neurodegeneration butunfortunatelythere currently is no effective pharmaceutical TBI treatmentThe underlying PhaseSTTR grant is to develop a new class of TBI drugs that inhibit the protease cathepsin BGenetically deleting the cathepsin B gene in mice results in substantial behavioral and pathology improve ...

ABSTRACT Infection is a serious and potentially fatal complication of surgery to deliver cardiovascular implantable electronic devicesCIEDsi epacemakers and implantable cardioverter defibrillatorsUntreated device related infection is associated with mortality rates as high asCurrentlyonly one antibiotic impregnated mesh has been FDA approved for placement in surgical incisions to reduce infections ...

ABSTRACT Pancreatic cancer is a disease with no effective treatmentIt s low five year survival rateestimated at betweenandranks it the fourth highest of cancer related of death in the U Sdespite being the twelfth most common type of cancerEach year in the U Sthere are nearlynew cases and more thandeaths caused by the diseaseBypancreatic cancer is expected to be the second most common cancer relate ...

NASA seeks to develop high specific energy primary batteries that are safe and capable of performing under a wide temperature range, for manned space missions. To meet this goal, CFX Battery Inc. proposes to develop, characterize, and establish technological feasibility of a new Li/SF-CFx based high capacity lithium primary battery that offers higher rate capability and enhanced safety than conven ...

DESCRIPTION (provided by applicant): We propose a novel and competitive urinary tract silicone Foley catheter made from a proprietary polymeric formulation to effectively reduce catheter-associated urinary tract infections (CAUTI) via nitric oxide (NO) release. Preliminary studies show that the device will be able to: (1) continuously deliver NO at rates enough to maintain bactericidal properties ...

In providing an innovative solution to improving information technologies and health management systems, AGNC is proposing a significant technological achievement with the Advanced Structural Health Monitoring System for Comprehensive Real-Time Vehicle Characterization. During in-flight conditions, this system is able to not only provide the status of information such as regarding the flight envel ...

The innovation proposed here is a high performance, high fidelity simulation capability to enable accurate, fast and robust simulation of unsteady turbulent, reacting flows involving cryogenic propellants (such as LOX/LH2 and LOX/LCH4). The key features of this proposed capability are: (a) Hybrid RANS-LES (HRLES) methodology, and (b) flamelet modeling for turbulent combustion incorporated in a pr ...