Award Data

To address the USSOCOM need to develop new materials or processes using nanotechnology for chemical and biological warfare (CBW) defense, Physical Optics Corporation (POC) proposes to develop a new Nanoparticle Adhesive Deposition (NANOPAD) process. This proposed process is based on established chemical finishing techniques using chemically synthesized metal hydroxide nanoplatelets (MHN) to impreg ...

The dynamics of nano-size interactions of metal hydroxide nanoplatelets is a new field of material science. Initial research conducted by Aqua Resources and the Department of Defense, offers the promise of an innovative means of effectively defending against Chemical/Biological (CB) warfare agents in a cost effective manner without the attendant residues and long-term damage associated with tradit ...

Molecular biology techniques allow generating combinatorial libraries of large number of enzyme variants. However, there is currently no technology available for screening the enzyme libraries for identifying variants with improved activity for the substrate. We propose to develop a novel, microfluidic, high-throughput platform for determining kinetic constants of enzyme variants and identifying v ...

A need exists for a new environmental situational awareness sensor with multi-spectrum camouflage that is extremely small (90g) and capable of measuring with aviation-grade accuracy: wind speed/direction, horizontal visibility, sky condition, cloud heights, temperature, dewpoint, barometric pressure, precipitation and CBRN contamination. There exists a strong desire to support a variety of commun ...

Current drug discovery and development programs are severely limited by the expensive animal trials and oversimplified in vitro models. Results obtained from the in vitro models are not predictive of in vivo toxicity owing to significant difference in testing from the in vivo physiological conditions. In this context, we propose to develop and demonstrate a novel microfluidic device for quantitati ...

To address the CBD need for improved formulations to enhance the ease of use and bioavailability of antisense therapeutics, Physical Optics Corporation (POC) proposes to develop a Multifunctional Antisense Therapeutics Nanocarrier and Inhalation Device (MATEN). This proposed system is based on a new dry powder formulation and a novel design of an inhaler that uses in-house developed mature compone ...

To address the Chemical/Bio Defense (CBD) need for in vitro models suitable for high-throughput screening of drug toxicities in human tissues, Physical Optics Corporation (POC) proposes to develop a new three-dimensional (3D) Microfluidic Platform for in-vitro Hematopoietic Stem Cell (HSC) Culture (3D-Mic-Stem). This proposed system is based on a 3D microfluidic design that uses HSCs for assaying ...

To address the U.S. Army/DTRA’s CBD program need for a robust screening process for use with large panels of enzymes to identify variants with higher affinity for organophosphorus (OP) substrates, Physical Optics Corporation (POC) proposes to develop a Microfluidic Dielectrophoretic Screening (MDS) system. This proposed system is based on the new design of a microfluidic mixer, enzymatic reactor ...

Redondo Optics Inc. (ROI), a world leader in engineering and manufacturing of leading-edge nano-materials, optical sensors, fiber and integrated optics, and advanced photonics instrumentation proposes to develop and demonstrate an integrated electrophoretic nanofluidic biochip sensor platform for the accurate, reliable, and fast-throughput “label-less” THz spectroscopy finger printing of biolo ...

To address the SOCOM need for live, day-and-night weather monitoring, Physical Optics Corporation (POC) proposes to develop a new Optical-Wave-Guide–Integrated Weather Sensor (WAGIS). This proposed device is based on a new design that utilizes in-house–developed mature components and COTS components. The innovation in multispectral optical train design and implementation of POC’s proprietary ...