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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. Targeting neurotoxic alpha-synuclein aggregates for Parkinson's disease therapy.

    SBC: Vova Ida, LLC            Topic: 999

    SUMMARYParkinsonandapos s diseasePDis the second most prevalent neurodegenerative disorder after Alzheimerandapos s diseaseADaffecting more thanmillion people in the United StatesBecause age is the major risk factorthe prevalence of both diseases is steadily increasing as our population agesPD belongs to the group of protein misfolding neurodegenerative diseases that are due to the misfolding and ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  2. A single dose long-acting non-addictive polymer conjugate formulation of buprenorphine that provides immediate and prolonged analgesia for post-operative pain

    SBC: SERINA THERAPEUTICS INC            Topic: NINDS

    PAProject Summary Abstract SERis a long acting polymer pro drug of buprenorphine that is being developed to treat postoperative pain following major surgeries such as bunionectomyabdominoplastythoracotomy and knee and hip surgerySERhas no biological activity by itselfbut when administered in vivo by subcutaneous injection it enters the vascular compartment where a plasma esterasebutyrylcholinester ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  3. Osteoactivin Treatment for Accelerating Spinal Fusion in Osteoporosis

    SBC: GPN THERAPEUTICS, INC.            Topic: R

    Project Summary Abstract Overspinal fusions are performed annually in the US of whichundergo revision due to failure to fuseThe mean age for spinal fusion increased fromtoyears inIn patients older thanyearsthe frequency of osteoporosis is reported to bein women andin manThese patients experience substantial deterioration in the quality of lifeincreased dependency on othersand reduced lifespanVerte ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  4. An Automated System to Locate Items Misplaced by Persons with Dementia in a Care Facility

    SBC: Applied Universal Dynamics, Corp.            Topic: NIA

    Abstract This application responds directly to the purpose of the PAR-18-588 SBIR Funding Opportunity Announcement (FOA). This project will develop an assistive system for caregivers of persons with dementia (PWD) to locate items that have been misplaced by PWD. A PWD who misplaces objects can create feelings of anxiety and frustration for both the PWD and the caregivers. The PWD can leave an obje ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  5. Developing novel fibrillin biomarkers for aortic disease

    SBC: Virogenomics BioDevelopment Inc            Topic: NHLBI

    PROJECT SUMMARY In the United Statesaortic aneurysmal disease ranks among the topleading causes of deathPatients with aortic aneurysmsAAsare typically asymptomatic until dissection and then symptoms resemble other ailmentswhich can delay a correct diagnosisMortality associated with aortic dissectionADis high and rapid due to rupture of the aortaReducing mortality from aneurysmal disease requires i ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  6. Technology-based Training Tool for an Empirically- Supported Group-Based HIV and STI Prevention Intervention for Juvenile Offenders

    SBC: Oregon Research Behavioral Intervention Strategies, INC            Topic: 102

    Summary AbstractYouth under ageinvolved in the criminal justice system are disproportionately minorities and affected by substance abusemental illnessand HIV STIMost young offenders are released on community supervision without the STImental healthor substance use screeningdiagnosisand treatment afforded detained youthdespite similar rates of risk behaviorTheir long term trajectory is poorthe cost ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  7. LystaMab Immunotherapy to Inhibit Pericardial Adhesions

    SBC: Lyst Therapeutics LLC            Topic: NHLBI

    SUMMARY Despite significant advances in the surgical and medical management of congenital heart diseasecongenital cardiac anomalies remain a leading cause of death in the newborn periodMost severe forms of congenital heart disease require multiplestaged surgical interventionsA significant source of the heightened morbidity and mortality associated with these operations is the development of cardia ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  8. Citizen-Science Technology for HealthyLiving at Home

    SBC: Access Sensor Technologies LLC            Topic: NIMHD

    Project Summary Environmental risk factors are attributable toof the chronic respiratory disease burden in the U Sand toof the burden from other non communicable diseasese gcancercardiovascular diseaseand diabetesExposure to environmental risk factors occurs through various forms of water and air pollutionwith a smaller attribution to sources like noiseradiationand physical hazardsMuch of this exp ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  9. Translating an In-Person Brief, Bystander Bullying Intervention (STAC) to a Technology-Based

    SBC: KLEIN BUENDEL, INC            Topic: 102

    Project Summary While studies support the efficacy of comprehensiveschool wide interventions in reducing bullyingthese types of programs can require significant time and financial resources for implementationresulting in barriers to providing school based bullying preventionespecially in low income and rural communitiesAdditionallyalthough training bystanders to act asdefenderson behalf of targets ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  10. A SAFE AND COMPACT NEONATE TO ADULT NEUROIMAGING MRI SYSTEM

    SBC: ADVANCED IMAGING RESEARCH, INC.            Topic: 101

    NIH SBIR PA-18-871 w/o Clinical Trials A Safe and Compact Neonate to Adult Neuroimaging MRI System The intriguing human brain is the most imaged end-organ non-invasively, without ionizing radiation using magnetic resonance imaging (MRI). High spatial resolution brain MRI is an established diagnostic tool to assess injury mechanisms affecting newborn growth and the adult human connectome. To predic ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
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