Award Data

Opportunity: Guayule, a US native plant, is the only alternate rubber crop with an established, mechanized, agronomic system. Problem: Low rubber yields and lack of effective resin and bagasse coproduct valorization, have prevented widespread adoption by American farmers and processors. Rubber is only made when the cytoplasmic monomer pool (isopentenyl-pyrophosphate; IPP) is larger than that requi ...

Traumatic injuries account for 30% of all life years lost in the US and is the leading cause of death for people under 46 years of age. Uncontrolled bleeding or hemorrhage constitute 30-40% of trauma related deaths and are considered to be a major cause o

Most standard-of-care tools and techniques for evaluating neck disorders are subjective, unreliable, and do not provide actionable information for providers, payers, and organizations to deliver efficient and effective care. This lack of objective neck he

The objective of this proposal is to examine the feasibility of defining and measuring key dimensions of an urban system to include its essential functions and networks, and whether they can be modelled in a computational framework for assessing robustness and resilience of DUTs (and their tipping points) under conditions of volatility and stress. This proposal will conduct a comprehensive review ...

This proposal is in response to the Defense Health Agency 2017 Phase I SBIR topic 17B-005.The approach is the use of a membrane oxygen pump using newly developed nano-thickness membranes with all the layers less than 1 micron total.Nanometer thickness membranes enable more oxygen output per surface area at temperatures of 300-600 C than current state-of-the -art 600-800 C membranes that are 50-300 ...

Approximately 70% of sentinel events in medical care are related to communication mishaps, and despite regular and frequent occurrence, an even higher percentage (80%) of severe medical errors are related to miscommunication during handoffs (i.e., the transferring of information, responsibility, and authority for patient care from one provider to another). The TiER1 team proposes to address challe ...

We propose to develop a high-resolution soft x-ray nanoscope based on Fourier Transform Holography which has the very important advantage for real time visualization: 3D images are nearly instantaneously retrieved with a simple 2D Fast Fourier Transform operation. The table-top soft x-ray nanoscope will use for illumination a compact high average power soft x-ray laser that generates high e ...

The objective is to design an analog (time-continuous) radiofrequency (RF) computation platform in the form of a software-defined RF integrated-circuit (IC) with supplementary digital logic for solving differential equation based simulations at speeds that are 1-2 orders of magnitude greater than available digital high-performance computation platforms. The maximum speed that the state-of-the-art ...

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Surgical simulations aiming to support surgeon practices and medical education have attracted enormous research effort over the last two decades. However, the physical reality, especially on simulating aggregated tissue interaction, is still unsatisfactory. In this proposed work, an open source surgery simulation framework, SoFMIS, will be utilized and enhanced with tissue interaction models to a ...