Award Data

Organophosphorus chemical warfare nerve agents (OP-CWA) are attractive to terrorist groups and rogue states as an inexpensive and accessible technology for chemical warfare. OP-CWA and organophosphate pesticides cause severe neurological symptoms and death by inhibiting the enzyme acetylcholinesterase (AChE); the resulting excess acetylcholine accumulates and overstimulates the human or animal bo ...

Leveraging on Agiltron’s industry leading development of optical MEMS devices and the PI’s experience with FTIR spectrometer design, we propose to develop a new class of high performance compact and rugged FTIR spectrometers for LWIR optical range. The design is based on the MEMS lamellar mirror technique. Although this approach is not new, it has not yet been efficiently applied to LWIR, and ...

Longwave infrared (LWIR, 8-12µm) focal plane arrays (FPAs) play an important role in hyperspectral chemical and biological sensing. Existing thermal detectors are unable to meet the high sensitivity and fast response requirements of many hyperspectral chemical and biological sensing applications. Photodetectors and FPAs based on photon excited electron generation process can fulfill the speed and ...

Current drug discovery and development programs are severely limited by the expensive animal trials and oversimplified in vitro models. Results obtained from the in vitro models are not predictive of in vivo toxicity owing to significant difference in testing from the in vivo physiological conditions. In this context, we propose to develop and demonstrate a novel microfluidic device for quantitati ...

Molecular biology techniques allow generating combinatorial libraries of large number of enzyme variants. However, there is currently no technology available for screening the enzyme libraries for identifying variants with improved activity for the substrate. We propose to develop a novel, microfluidic, high-throughput platform for determining kinetic constants of enzyme variants and identifying v ...

Guild Associates, Inc. proposes to develop and evaluate an active electrochemical sensor based residual life indicator (RLI) for adsorptive carbon filters. The sensing system of the RLI will operate by analyzing the electrochemical state of the carbon within the filter and evaluate the remaining adsorptive reactive capacities of the filter. The sensor design will be challenged against an array of ...

The goal of this project is to field an easy-to-use but highly capable cohort builder, integrated with Military Health System (MHS) data resources, that will enable clinicians, nurses and QA personnel to efficiently conduct clinical quality assurance and comparative effectiveness research studies, and to identify groups of chronically ill patients for whom there are opportunities for care remediat ...

Peripheral neuropathy (PN) is condition in which a single nerve, nerve groups, or nerves become damaged. Neuropathic pain can be difficult to manage. Mild pain can be treated with over the counter analgesics. In cases when the pain is persistent and more severe, injections of, or topical patches containing local anesthetics, can be used. In order to provide a safe and no adverse side effect PN pai ...

Junctional and inguinal bleeding is a significant and challenging problem on the battlefield. Inventors have developed new types of tourniquets, including the Abdominal Aortic Tourniquet (AAT) and the Combat Ready Clamp (CRoC) to address these abdominal and pelvic injuries. While these hemorrhage control technologies have been developed, validated, and approved for use, training systems that teach ...

The US Department of Defense identified a continuing need for antimicrobial textiles to provide a range of capabilities such as integration in Soldier uniforms to control odor or in medical textiles to control the transmission of pathogenic bacteria. Physical Sciences Inc. (PSI) proposes to functionalize fabrics with novel antimicrobial dendrimers. These compounds will be used as a textile finish ...