Award Data

Nerve agents exert their toxic effect by binding to and inactivating enzyme acetylcholinesterase, a key enzymatic regulator of cholinergic neurotransmission. The binding becomes irreversible after a varying amount of time with nerve agents and this aging process limits the treatment window of oxime reactivators. To enhance the current antidote treatment of nerve agent autoinjectors, a pyridostigmi ...

CMC Pharmaceuticals, Inc. (Cleveland, OH) is proposing developing a stable, combination product of two small molecule drug candidates as a counter measure to chemical warfare nerve agents (NA). The combination product is expected to exploit complementary pharmacological profiles for optimal muscarinic receptor blockade and anticholinergic activity within the peripheral and central nervous system. ...

We propose a novel two-dimensional mass spectrometry (2D-MS) technique based on ion trap arrays to identify illicit and designer drugs. This approach will give an unprecedented multiplex advantage for miniature mass spectrometry, allowing novice field technicians to rapidly identify drugs affecting the central nervous system based on both the m/z ratio and fragmentation pattern of an ion. Towards ...

Highly pathogenic alphaviruses like VEEV/EEV/WWEEV cause encephalitis in humans and equids. These infections are endemic in wide regions of the developing world. Translational research regarding these pathogens is focused on developing new strategies to detect, treat and ideally protect humans and animals from these infections. Gene-encoded antibodies against alphavirus E1/E2 surface proteins will ...

Care for the wounded Warfighters in austere and remote settings makes medical knowledge, skills and efficiency of the military medical professional paramount. For wounds that extend deep into internal anatomy, proper visualization of internal anatomy can

BioMojo proposes to develop a language-based intelligent patient simulation platform for the purpose of providing students with a realistic training environment and instructors better control over the training environment involving simulated patients.

A proof-of-concept research on Intelligent Patient Platform is proposed with the goal to improve healthcare training experience by adding natural language capability to patient simulators by leveraging the latest artificial intelligent technologies so tha

The Defense Health Agency has identified the need for an advanced computing and networking capability to support unfettered operation of Electronic Medical Records (EMR) systems in delayed/disconnected, intermittently-connected, low-bandwidth (DIL) enviro

Nanohmics proposes to develop a radically new type of general water toxicity monitor based on the widely published principle that many eukaryotic (including yeast) cell lysosomes swell and increase in numbers in response to pollutants in water within 30-6

Veterans with amputations are relatively common as a result of war and peace keeping efforts. The civilian amputee population is also steadily growing as a result of vascular disease. For many years, there has been an emphasis on the development of prosth