Award Data

Traumatic injuries account for 30% of all life years lost in the US and is the leading cause of death for people under 46 years of age. Uncontrolled bleeding or hemorrhage constitute 30-40% of trauma related deaths and are considered to be a major cause o

The modern warfighter faces the constant threat of endemic infections, multi-drug resistant bacteria and Biological Warfare Agents. In order to provide accurate front-line treatment that will curtail the overuse of antibiotics, a rapid and robust molecula

Realistic surgical simulation requires a combination of representative tissue geometry, accurate tissue material properties and lifelike tool-tissue interaction forces. Recent advances in computational power and imaging modalities have provided the capability to represent the anatomical details required for surgical training; however, the mathematical models which govern the underlying tissue pro ...

Between Operation Iraqi Freedom, Operation Enduring Freedom, and Operation New Dawn, the total number of U.S. Casualties (those Wounded in Action) has exceeded 52,000 as of January 30, 2015. These numbers point to the fact that active warfighters in the battlefield are almost constantly exposed to the threat of external penetrating wounds. The goal of combat wound care is to protect open wounds u ...

This proposal is in response to the Defense Health Agency 2017 Phase I SBIR topic 17B-005.The approach is the use of a membrane oxygen pump using newly developed nano-thickness membranes with all the layers less than 1 micron total.Nanometer thickness membranes enable more oxygen output per surface area at temperatures of 300-600 C than current state-of-the -art 600-800 C membranes that are 50-300 ...

This Small Business Technology Transfer (STTR) Phase I effort will demonstrate the feasibility of using piezoelectric fibers to detect shock waves from underwater explosions (UNDEX) and sensing physiological measures such as heart and respiratory rates on warfighters. Piezoelectric fibers will be characterized for their ability so sense different amplitudes and frequencies of shock and vibration. ...

Drug dosingcan bemademore precise by using pharmacokineticand pharmacodynamicmodeling. Pharmacokinetics is thestudy of the concentration of drugs in tissueasafunction of timeand doseschedule,whereas pharmacodynamics is thestudy of therelationship between drugconcentration and drugeffect. By relating doseto resultant drugconcentration (pharmacokinetics)and concentration to effect (pharmacodynamics) ...

Approximately 70% of sentinel events in medical care are related to communication mishaps, and despite regular and frequent occurrence, an even higher percentage (80%) of severe medical errors are related to miscommunication during handoffs (i.e., the transferring of information, responsibility, and authority for patient care from one provider to another). The TiER1 team proposes to address challe ...

The ready availability of universal donor plasma to rapidly treat massively bleeding hospital trauma patients and warfighters with combat casualties is a key element of current recommendations for trauma resuscitation, yet universal AB donor plasma is rel

BioMojo LLC and the Departments of Mathematics and Biomedical Engineering at the University of North Carolina Chapel Hill, will develop a preliminary bio mathematical model framework to represent how human tissues interact and behave at their boundaries. Tissue interaction properties (e.g. tensile, shear, friction, and so forth) of connective, epithelial, muscular, and nervous tissue including su ...