Award Data

DESCRIPTION: The specific objective of this STTR Phase II research and development project is to provide an optimized cellular therapy regimen for treating hypoxic-ischemic (HI) injury and its related outcomes in neonates. Pre- clinical studies performed in a rat pup model of HI injury as part of the funded Phase I STTR grant, point to benefit when Multipotent Adult Progenitor Cells (MAPC), a plur ...

DESCRIPTION (provided by applicant): This project seeks to develop an earphone for diagnostic audiometry with features that will significantly increase the efficiency and decrease the cost of routine hearing testing. The most-often used earphones employ a supra-aural design that has several undesirable characteristics, including 1) an "occlusion effect", an artificial increase in sensitivity to bo ...

DESCRIPTION (provided by applicant): The blood-brain barrier (BBB) is crucial for complex issues such as drug delivery, pathogenesis of chronic neurological diseases involving BBB dysfunction (e.g., brain tumors, ischemia, hypoxia, brain edema, multiple sclerosis, and meningitis) and issues related to bio-defense. Since the BBB selectively (by specific transport mechanisms) excludes most blood-bor ...

DESCRIPTION (provided by applicant): Over the past twenty-five years, there has been a sharp rise in the number of children and adolescents presenting to emergency departments (EDs) for psychiatric issues. Given that youth mental health issues account for 1.6% - 5.0% of all ED visits, and that Emergency Medicine physicians are the first to interact with these youth, the assessment of psychiatric i ...

FSU and CME developed an ocean-going, energy-scavenging platform for long-range surveillance. The objective was to develop and demonstrate energy scavenging technology for a low cost, autonomous surface vehicle that obtained all its power from the environment. The study included several areas of energy harvesting including renewable sources such as solar and wind, and non-renewable sources such a ...

DESCRIPTION (provided by applicant): The overall goal of this Phase II project is to develop a novel R1-based method for MRI quantification of postinfarct myocardial viability using a commercially available contrast agent Gd(DTPA). The commercial embodiment of this method will be a software package that will convert a set of 2D cardiac MRI images to a 3D myocardial viability map, the Percent Infa ...

DESCRIPTION (provided by applicant): The field of cranio-maxillofacial (CMF) surgery involves the correction of congenital and acquired deformities of the skull and face. These include dentofacial deformities, congenital deformities, and defects after tumor ablation, post-traumatic defects, and deformities of the temporomandibular joint (TMJ). In the United States each year, a significant number o ...

In diverse application areas there is a need to develop magnetic field sensors which resolve small (nanoTesla-level) field perturbations at low (Hertz and milliHertz) frequencies. The emerging technology of spin-dependent tunneling is promising in that its attributes include low power, small size, low cost, IC compatibility (uses standard silicon microelectronics processing), and broad-band frequ ...

DESCRIPTION (provided by applicant): Cholestasis (pathologic jaundice) is a very common sign of liver disease in children and adults, and results from genetic defects that play a critical role in bile formation and transport. In adults, mutations in the same genes also cause debilitating liver diseases or increased susceptibility to common biliary diseases, such as gallstones. Because many of the ...

DESCRIPTION (provided by applicant): The objective of this application is to enable more efficient and cost-effective utilization of solid-state NMR systems for health care research. Solid-state NMR spectroscopy is an important tool for the analysis of pharmaceuticals and biological compounds such as proteins, but is often not used due to the length of time required to collect data. The specific a ...