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Award Data

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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. Accelerating Site-specific Characterization of Protein Therapeutics with Novel Machine Learning Methods

    SBC: MASSMATRIX, INC.            Topic: 400

    PROJECT SUMMARYABSTRACT TitleAccelerating Site specific Characterization of Protein Therapeutics with Novel Machine Learning Methods The project seeks to improve reliability and speed up the development of life saving and life enhancingprecisionprotein therapeutics and magnify the positive impact of biomedical research and education worldwideleading to a quantum leap in our understanding of the mo ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  2. A CD8+ T cell diagnostic to identify children with pulmonary tuberculosis

    SBC: ViTi, Inc            Topic: NIAID

    DESCRIPTION provided by applicant Tuberculosis TB disease which results from infection with Mycobacterium tuberculosis Mtb is a leading cause of infectious morbidity and mortality in children andlt years old worldwide In TB endemic regions in which the vast majority of the worldandapos s annual million adult cases of TB disease reside children andlt years old account for ...

    SBIR Phase II 2013 Department of Health and Human ServicesNational Institutes of Health
  3. A Cell-based Assay for Botulinum Neurotoxin Detection and Development

    SBC: Q-Track Corporation            Topic: NIEHS

    DESCRIPTION (provided by applicant): The proposed effort aims to dramatically enhance the realism of radiation safety training for Emergency Responders, both First Responders, as well as Skilled Support Personnel. The goal is to develop andevaluate realistic dosimetry simulation or Dosimulation tools. These Realistic, Accurate Dosimulation (RAD) tools will be the centerpiece for ...

    SBIR Phase I 2013 Department of Health and Human Services
  4. A compact, modular two-photon fiber-coupled microscope for in vivo all-optical electrophysiology

    SBC: INTELLIGENT IMAGING INNOVATIONS, INC.            Topic: 101

    Good methods to interrogateand ideally perturbneural systems at the network level have been elusive until recentlyThe advent of biochemical breakthroughsnamely neuronally targeted genetically encoded calcium reporterssuch as GCaMPand light activated channelssuch as channelrhodopsinhave enabledall opticalelectrophysiology where experiments can be conducted that involve simultaneousor closely sequen ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  5. A computational platform to improve the prioritization of drugs and target genes for therapeutic intervention

    SBC: Genetic Networks, LLC            Topic: 100

    Project Summary This project proposes further development of a computational discovery platform shown to quantifiably identify and prioritize both targets and compounds for therapeutic interventionwhich will accelerate the development of newermore effective drugs with fewer side effectsThis platform is based on a novel fusion of two state of the art computational approachesphenolog mapping and fun ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  6. A cost-effective bioreactor to advance functional tissue engineering of cartilage

    SBC: APEX BIOMEDICAL COMPANY, LLC            Topic: NIAMS

    DESCRIPTION (provided by applicant): Osteoarthritis (OA) is the leading cause of chronic disability in the United States. A clinical goal in the treatment and prevention of OA is to develop replacement cartilage using tissue engineering (TE) technologies. Although TE cartilage presently lacks the mechanical stability of native cartilage, studies have demonstrated that mechanical stability can be e ...

    STTR Phase I 2010 Department of Health and Human Services
  7. Activity of Fully Deleted Helper-Virus Independent Adenoviral Gene Therapy Vector

    SBC: ISOGENIS, INC.            Topic: NIAID

    DESCRIPTION (provided by applicant): Numerous diseases are caused by gene defects. The goal of gene therapy is the effective treatment or cure of these diseases by the introduction of the normal gene or repair of the gene defect. A large research effort has been mounted to optimize gene transfer vectors mostly based on adenoviruses and retroviruses. Yet, the initial promise of gene therapy has bee ...

    SBIR Phase I 2010 Department of Health and Human Services
  8. A custom microchip amplifier for patch clamp electrophysiological recording

    SBC: MAINSTREAM ENGINEERING CORPORATION            Topic: NIEHS

    DESCRIPTION: An estimated 2.5 billion people, or about one-third of the world's population, rely on biomass fuel for cooking. Emissions from biomass cook stoves contribute to global climate change, indoor/local air quality issues, and related health effects. In particular, indoor ir quality issues related to biomass cook stoves contribute significantly to rates of acute respiratory infection ...

    SBIR Phase I 2013 Department of Health and Human Services
  9. Acute-infarct selective cardiac MRI contrast agent

    SBC: ELGAVISH PARAMAGNETICS, INC.            Topic: NHLBI

    DESCRIPTION provided by applicant The overall goal of this project is to demonstrate the ability of our acute myocardial infarct selective paramagnetic contrast agent Gadolinium ABE DTTA to differentiate between acute and chronic infarcts in a reliable manner using contrast enhanced magnetic resonance imaging ceMRI In our Phase I data we have shown that Gd ABE DTTA exclusively highlight ...

    STTR Phase II 2010 Department of Health and Human ServicesNational Institutes of Health
  10. A Cytomegalovirus-based therapeutic vaccine for chronic hepatitis B

    SBC: TOMEGAVAX, INC.            Topic: R

    Abstract Although an efficient prophylactic vaccine is available for hepatitis B virusHBVchronic hepatitis BCHBaffects up tomillion people worldwideand despite advances remains mostly incurableIn adultsacute HBV infection is cleared inof cases by CDT cell mediated mechanismsbut chroniclifelong infection ensues in the remaining individualswhich can lead to liver cirrhosis and cancerThe induction an ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
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