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The Award database is continually updated throughout the year. As a result, data for FY21 is not expected to be complete until September, 2022.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

  1. Microfluidic High-throughput Platform for Determining of Kinetic Constants of Enzyme Variants

    SBC: CFD Research Corporation            Topic: CBD10107

    Molecular biology techniques allow generating combinatorial libraries of large number of enzyme variants. However, there is currently no technology available for screening the enzyme libraries for identifying variants with improved activity for the substrate. We propose to develop a novel, microfluidic, high-throughput platform for determining kinetic constants of enzyme variants and identifying v ...

    SBIR Phase I 2010 Department of DefenseOffice for Chemical and Biological Defense
  2. A Novel Microfludic Device for Drug Toxicity Studies

    SBC: CFD Research Corporation            Topic: CBD10103

    Current drug discovery and development programs are severely limited by the expensive animal trials and oversimplified in vitro models. Results obtained from the in vitro models are not predictive of in vivo toxicity owing to significant difference in testing from the in vivo physiological conditions. In this context, we propose to develop and demonstrate a novel microfluidic device for quantitati ...

    SBIR Phase I 2010 Department of DefenseOffice for Chemical and Biological Defense
  3. AC Impedance Sensor for Collective Protection Filter Residual Life Indicator

    SBC: Guild Associates, Inc.            Topic: CBD10106

    Guild Associates, Inc. proposes to develop and evaluate an active electrochemical sensor based residual life indicator (RLI) for adsorptive carbon filters. The sensing system of the RLI will operate by analyzing the electrochemical state of the carbon within the filter and evaluate the remaining adsorptive reactive capacities of the filter. The sensor design will be challenged against an array of ...

    SBIR Phase I 2010 Department of DefenseOffice for Chemical and Biological Defense
  4. Prototype Application of Mobile, Cloud-based, Watson-Like Technologies for TBI/PTSD Clinical Decision Support and Predictive Analytics

    SBC: Lifecom Inc.            Topic: DHP12005

    The goal of this Phase I project is to develop an engineering plan and to create a prototype for a mobile, cloud-based expert system to aid in diagnosis, decision support and predictive analytics to improve clinical outcomes for veterans, soldiers, and their families with traumatic brain injury (TBI) and posttraumatic stress disorder (PTSD). Lifecom, Inc. is a health information technology compan ...

    SBIR Phase I 2013 Department of DefenseDefense Health Agency
  5. An automated, high throughput, resin-free device for large scale protein purification

    SBC: CFD Research Corporation            Topic: CBD12102

    Protein manufacturing is of paramount importance to chemical and biological defense applications. High-throughput protein purification is a critical need for rapidly scaling the target protein product. Existing purification methods primarly rely on synthetic-resin based chromatography, which is time-consuming, labor-intensive, expensive, and consequently, ill-suited for developing rapid countermea ...

    SBIR Phase I 2013 Department of DefenseOffice for Chemical and Biological Defense
  6. Ear Protection Validation System

    SBC: Benson Medical Instruments Company            Topic: DHP12009

    This proposal contains the description for a hearing protection device (HPD) fit-test instrument, the CCA-200fit. The CCA-200fit has the capability to determine if an individual is receiving effective noise protection from an HPD. The CCA-200fit also has training capabilities via a display, audio, and a touchscreen which will allow it to provide instruction, feedback, and results to the individual ...

    SBIR Phase I 2013 Department of DefenseDefense Health Agency
  7. Development of Technologies that Control Scar Contracture after Burn Injuries

    SBC: Quick-Med Technologies, Inc.            Topic: DHP12016

    Current therapies to prevent scar formation and contracture of burns are minimally effective. QuickMed Technologies (QMT) proposes to develop an advanced therapy to enhance healing and prevent contraction of burn scars by combining the advanced prototype BURN-PLUS dressing with Endoform dermal template. BURN-PLUS is an occlusive island dressing with an adhesive apron bonded onto a super absorben ...

    SBIR Phase I 2013 Department of DefenseDefense Health Agency
  8. Multisegmental Sensor Integration for Balance Control

    SBC: Engineering Acoustics Incorporated            Topic: DHP12008

    Fall-related events are the leading cause for injury deaths among people 65 years and older. Blast related balance dysfunction is a significant problem the military. Recent advances in Micro-Electrical-Mechanical Systems (MEMS) have made accessible a variety of extremely small, rugged, reliable, low power consumption, and inexpensive sensors of acceleration and pressure. A collection of these devi ...

    SBIR Phase I 2013 Department of DefenseDefense Health Agency
  9. A Novel, Aerodynamics-augmented Continuous Ionization System for Electrostatic Collection of Bioaerosols

    SBC: CFD Research Corporation            Topic: CBD12107

    Safe and efficient air ionization and filtration technology compatible to biodefense applications is of paramount importance. Current ionization methods are energy-intensive, costly, prone to ozone generation, or inefficient, and consequently ill-suited for building protection applications. To overcome these issues, we propose to develop and demonstrate a novel bioaerosol ionization and collection ...

    SBIR Phase I 2013 Department of DefenseOffice for Chemical and Biological Defense
  10. Exploiting Natural Products-Based Therapeutics for Aflatoxin Mitigation

    SBC: CFD Research Corporation            Topic: CBD152003

    Aflatoxins are a paradigm among fungal produced mycotoxins that are present in food supplies and are strongly associated with increased risk forthe development of hepatocellular carcinoma. Currently, there are no known countermeasures that can selectively mitigate aflatoxin toxicity andthe available options are only symptomatic treatments. To meet this challenge, we propose to harness the microbio ...

    SBIR Phase I 2016 Department of DefenseOffice for Chemical and Biological Defense
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