Award Data

Project Summary/Abstract Objective: This project aims to elevate electron beam therapy (EBT) technology, which provides effective radiation treatment for superficial cancers (depthandlt;6 cm), to that of other external beam radiotherapies (XRT), e.g. x-rays and protons, by bringing electron intensity modulation into the clinic. Challenge: Approximately 10% of radiotherapy patients (173,000 in U ...

Project Summary The successful management of chronic pain is inadequate in many patients and has contributed to the abuse of and addiction to opioidsa continuing major public health crisis in the United States and worldwideThe development of non addictive pain therapeutics can help counter opioid addiction and benefit patientsincluding those who suffer from neuropathic painand in particular diabet ...

PAProject Summary Abstract SERis a long acting polymer pro drug of buprenorphine that is being developed to treat postoperative pain following major surgeries such as bunionectomyabdominoplastythoracotomy and knee and hip surgerySERhas no biological activity by itselfbut when administered in vivo by subcutaneous injection it enters the vascular compartment where a plasma esterasebutyrylcholinester ...

Abstract: Thoracotomy is one of the most painful surgical procedures and patients are at high risk of developing opioid addiction. Recent studies have shown 1 in 7 patients became new persistent opioid users after physical recovery from the surgery was complete. The largest risk factor for opioid addiction is being prescribed opioids in the first place, and Thermaquil wants to reduce this incidenc ...

In the Phase II project, METSS will continue the development of a safe, robust, rapid, and effective chlorine dioxide (ClO2) gas dispersion system to be used for on-site room decontamination in hospital and non-hospital settings. The heart of the decontamination system is a proprietary ClO2 generating micro-reactor technology that is used to quickly and safely generate ClO2 on-site. This technolog ...

New regulations and advisory levels for perfluoroalkyl substances have resulted in increased drinking water treatment costs or abandonment of drinking water sources. Treatment technologies are needed that can achieve low parts-per-trillion levels. Presently, there are insufficient treatment technologies that can destructively remove perfluorooctanoic acid (PFOA) and/or perfluorooctane sulfonic aci ...

Project Summary Abstract Clinical decision supportCDSis a process for enhancing health related decisions and actions with pertinentorganized clinical knowledge and patient information to improve healthcare deliveryFor exampledoctors may have trouble remembering to order all guideline recommended care for sepsisCDS delivered via an order set in the electronic health recordEHRcan simplify this proce ...

ABSTRACT SUMMARY In previous studies we identified novel non hematopoietic umbilical cord blood stem cellsnhUCBSCsthat could be expanded to high passages and exhibit restorative properties following ischemic brain injury repairWe found that the high passaged cells were equivalentif not even betterthan the low passaged nh UCBSCsThis finding suggests that these cells can serve as a source of highly ...

Nonalcoholic steatohepatitisNASHis a serious health condition associated with the accumulation of lipids in the liver which leads to chronic inflammationThis inflammation can predispose affected individuals to serious downstream health problems including cirrhosis and hepatocellular carcinomaNASH occurs in a wide variety of patients but has a number of known risk factorsincludingobesityglucose int ...

NIH SBIR PA-18-871 w/o Clinical Trials A Safe and Compact Neonate to Adult Neuroimaging MRI System The intriguing human brain is the most imaged end-organ non-invasively, without ionizing radiation using magnetic resonance imaging (MRI). High spatial resolution brain MRI is an established diagnostic tool to assess injury mechanisms affecting newborn growth and the adult human connectome. To predic ...