Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until June, 2020.

  1. Product Development of Intensity Modulation for Bolus Electron Conformal Therapy

    SBC: Decimal, LLC            Topic: 102

    Project Summary Abstract ObjectiveThis project aims to elevate electron beam therapyEBTtechnologywhich provides effective radiation treatment for superficial cancersdepthandltcmto that of other external beam radiotherapiesXRTe gx rays and protonsby bringing electron intensity modulation into the clinicChallengeApproximatelyof radiotherapy patientsin USA annuallyreceive EBT for a portion of their t ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  2. A single dose long-acting non-addictive polymer conjugate formulation of buprenorphine that provides immediate and prolonged analgesia for post-operative pain

    SBC: SERINA THERAPEUTICS INC            Topic: NINDS

    PAProject Summary Abstract SERis a long acting polymer pro drug of buprenorphine that is being developed to treat postoperative pain following major surgeries such as bunionectomyabdominoplastythoracotomy and knee and hip surgerySERhas no biological activity by itselfbut when administered in vivo by subcutaneous injection it enters the vascular compartment where a plasma esterasebutyrylcholinester ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  3. Stem Cells for Treating Acute Stroke

    SBC: SANERON CCEL THERAPEUTICS, INC.            Topic: 999

    ABSTRACT SUMMARY In previous studies we identified novel non hematopoietic umbilical cord blood stem cellsnhUCBSCsthat could be expanded to high passages and exhibit restorative properties following ischemic brain injury repairWe found that the high passaged cells were equivalentif not even betterthan the low passaged nh UCBSCsThis finding suggests that these cells can serve as a source of highly ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  4. A SAFE AND COMPACT NEONATE TO ADULT NEUROIMAGING MRI SYSTEM

    SBC: ADVANCED IMAGING RESEARCH, INC.            Topic: 101

    NIH SBIR PAw o Clinical Trials A Safe and Compact Neonate to Adult Neuroimaging MRI System The intriguing human brain is the most imaged end organ non invasivelywithout ionizing radiation using magnetic resonance imagingMRIHigh spatial resolution brain MRI is an established diagnostic tool to assess injury mechanisms affecting newborn growth and the adult human connectomeTo predict neurodevelopmen ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  5. Audiometric Behavioral Response Simulator

    SBC: Intelligent Hearing Systems Corp.            Topic: Y

    The aim of this project is to develop an audiometric testing response simulatorSimulators are quickly becoming a critical component in the training of professionals across all fieldsThe proposed simulator is intended to be used in any environment where behavioral response audiometric testing is conductedthe foundation of most auditory assessmentsThe simulator will have the capability to connect wi ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  6. LystaMab Immunotherapy to Inhibit Pericardial Adhesions

    SBC: Lyst Therapeutics LLC            Topic: NHLBI

    SUMMARY Despite significant advances in the surgical and medical management of congenital heart diseasecongenital cardiac anomalies remain a leading cause of death in the newborn periodMost severe forms of congenital heart disease require multiplestaged surgical interventionsA significant source of the heightened morbidity and mortality associated with these operations is the development of cardia ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  7. A Next Generation, Low Cost Tracking System for Healthcare Process Validation (2)

    SBC: GaN Corporation            Topic: 600

    PROJECT SUMMARY SignificanceAmericaandapos s health care system remains challenged by tens of billions of dollars of fraud and inefficienciesLost and stolen equipment cost about $per hospital bedincreasing to $when expenses incurred from out of place equipment are addedIn additionareport estimates $billion was lost to fraudwasteabuseand other improper payments in the Medicare and Medicaid programs ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  8. Development of Inhibitors of cANGPTL4 for Pancreatic Cancer Therapeutics

    SBC: CFD Research Corporation            Topic: 102

    This project seeks to develop inhibitors of a novel pancreatic ductal adenocarcinomaPDACprotein targetPDAC remains one of the deadliest cancers with an average survival ofmonths for non resectable tumorsCurrentlya major obstacle in PDAC treatment is that the cells rapidly exhibit resistance to existing untargeted treatment regimens leaving patients with no further optionsStudies indicate that inhi ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  9. beta-Catenin inhibitors: A novel immuno-therapy for Colorectal Cancer

    SBC: Venn Therapeutics, LLC            Topic: 100

    ABSTRACT Although cancer immunotherapy is considered a great breakthrough in cancer therapya significant proportion of patients do not respond to these treatmentsRecent studies have shown that clinical benefits of the most potent immunotherapy lay in the presence of a T cell inflamed tumor microenvironment at baselinehot tumorDysregulated Wntcatenin signaling has been implicated in the lack of imm ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  10. Making Standing Balance The Fifth Vital Sign in Clinical Settings

    SBC: Bertec Corporation            Topic: NIA

    Falls are a significant source of early morbidity and mortality in the aging populationyet the neurologicalsensoryand motor changes that lead to increased fall risk often escape early identification and interventionVital signs are commonly used in clinical settings to assess the cardiovascular systemblood pressureheart rateimmune systembody temperatureand the respiratory systemrespiratory rateto e ...

    STTR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
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