Award Data

Project Summary/Abstract Objective: This project aims to elevate electron beam therapy (EBT) technology, which provides effective radiation treatment for superficial cancers (depthandlt;6 cm), to that of other external beam radiotherapies (XRT), e.g. x-rays and protons, by bringing electron intensity modulation into the clinic. Challenge: Approximately 10% of radiotherapy patients (173,000 in U ...

PAProject Summary Abstract SERis a long acting polymer pro drug of buprenorphine that is being developed to treat postoperative pain following major surgeries such as bunionectomyabdominoplastythoracotomy and knee and hip surgerySERhas no biological activity by itselfbut when administered in vivo by subcutaneous injection it enters the vascular compartment where a plasma esterasebutyrylcholinester ...

PROJECT SUMMARY Osteogenesis imperfectaOIalso known asbrittle bone diseaseis a genetic disease in which patients have defects in the formationstructureor strength of their bonescausing them to break easilyOI patients exhibit impaired tissue development and bone regeneration due to inherited mutations in one of the collagen genesleading to skeletal defectsbone fragilitydentinogenesis imperfectahear ...

ABSTRACT SUMMARY In previous studies we identified novel non hematopoietic umbilical cord blood stem cellsnhUCBSCsthat could be expanded to high passages and exhibit restorative properties following ischemic brain injury repairWe found that the high passaged cells were equivalentif not even betterthan the low passaged nh UCBSCsThis finding suggests that these cells can serve as a source of highly ...

Abstract In this Phase II SBIR project, ASTER Labs will enhance a hands-free automatic oral hygiene device in the form of a comfortable mouthpiece that was designed and successfully tested and evaluated during a Phase I study for persons with oral hygiene disabilities and their caregivers, and then investigate the device’s efficacy in reducing dental plaque and reducing burden, thereby improving ...

NIH SBIR PA-18-871 w/o Clinical Trials A Safe and Compact Neonate to Adult Neuroimaging MRI System The intriguing human brain is the most imaged end-organ non-invasively, without ionizing radiation using magnetic resonance imaging (MRI). High spatial resolution brain MRI is an established diagnostic tool to assess injury mechanisms affecting newborn growth and the adult human connectome. To predic ...

ABSTRACT Liver transplantation currently represents the only treatment for end stage liver disease (ESLD), the 8th most frequent cause of death in the United States (US). Efforts to overcome the chronic shortage of transplantable human livers include attempts at alternative organ procurement and replacement strategies. The most promising approach to date that provides the appropriate matrix compos ...

Project Summary/Abstract Advanced Medical Electronics Corporation and our partners propose to develop a Socially-Assistive Robot (SAR) system for persons with dementia (PWD),(mild cognitive impairment, Alzheimerandapos;s disease, or other dementias), who are living in assisted living facilities. The proposed system uses Augmented Intelligence (AI) to communicate with the PWD in natural language. T ...

Project Summary Abstract The proposed project focuses on creating a bariatric mannequin simulator to educate healthcare students on proper techniques specific and specialized to bariatric patient careSignificanceObesity is one of the world s most significant and growing health problemsMore thaninadults are overweight or have obesity and obese patients have a greater likelihood of requiring clinica ...

The aim of this project is to develop an audiometric testing response simulatorSimulators are quickly becoming a critical component in the training of professionals across all fieldsThe proposed simulator is intended to be used in any environment where behavioral response audiometric testing is conductedthe foundation of most auditory assessmentsThe simulator will have the capability to connect wi ...