Award Data

DESCRIPTION provided by applicant DiscoveryBioMed Inc DBM completed recently Phase I SBIR funded goals milestones specific experimental aims and efforts to screen synthetic organic small molecules on immortalized and primary differentiated human adipocyte platforms and to validate the high throughput screening HTS based Drug Discovery output with a Critical Path of bioassays dete ...

DESCRIPTION provided by applicant After an interim period of inactivity based on a select alternative commercial focus and after consultation with the FDA Neoprobe Corporation is rapidly reinitiating efforts to develop and commercialize Iodine labeled HuCC CH anti Tumor Associated Glycoprotein TAG monoclonal antibody construct as an aid to cancer surgeons who are operating on pa ...

DESCRIPTION provided by applicant It is predicted that approximately people will be diagnosed with nonmelanoma skin cancer this year in the United States Seventy five percent of these patients will undergo traditional excisional surgery i e non Mohs Micrographic Surgery non MMS Unlike MMS surgery traditional excision surgeries do not employ methods to determine the status of the ...

DESCRIPTION provided by applicant For tesla full body MRI bore magnet systems NbTi superconductor wire has reached its limit at K Above T if NbTi is used it requires super cooling of helium to K to achieve T bore MRI and NMR systems All these T full body MRI background magnets sold by Siemens Philips and GE have been manufactured by Aligent formerly known at Varian befor ...

DESCRIPTION provided by applicant The goal of this proposal is to develop tumor necrosis factor a TNFa inhibiting compounds as neuroprotectant drugs for treating Alzheimerandapos s disease AD Current FDA approved AD interventions are symptomatic treatments with limited efficacy which do not affect AD etiology or modify the course of disease progression Thus a critical need exists for a n ...

DESCRIPTION provided by applicant Despite advances in cancer therapy the majority of cancer therapeutics in use still exhibit significant toxicity and induce DNA damage The DNA damage though toxic to non malignant cells often plays an important role in killing cancer cells through the induction of p Recently in order to develop less toxic and more targeted cancer therapies alternative ...

DESCRIPTION provided by applicant The long term goal of this research is to commercialize a neurostimulation system to treat post amputation pain Approximately million individuals in the U S are living with an amputation and about individuals undergo an amputation each year Post amputation pain has a high incidence and frequently causes further disability depression and ...

DESCRIPTION provided by applicant The proposed effort aims to enhance the realism of radiation safety training for Emergency Responders both First Responders as well as Skilled Support Personnel Our goal is to develop and evaluate realistic dosimetry simulation or andquot Dosimulationandquot tools These andquot Realistic Accurate Dosimulationandquot RAD tools will be the centerpiece fo ...

DESCRIPTION provided by applicant Cardiovascular disease CVD represents a significant unmet medical need with over million patients in the United States suffering from acute myocardial infarction AMI each year This epidemic of heart attacks also represents a risk factor for further cardiovascular disease with over million individuals suffering from chronic heart failure CHF and an ...

DESCRIPTION provided by applicant The objective is to engineer build and clinically validate DBS Expert an expert system for optimizing postoperative programming of deep brain stimulation DBS in patients with movement disorders such as Parkinsonandapos s disease PD The clinical utility of DBS for treatment of PD is well established However great outcome disparity exists among recipien ...