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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Single Therapy for Wet AMD & Geographic Atrophy

    SBC: Novelmed Therapeutics Inc            Topic: W

    DESCRIPTION provided by applicant Approximately of the total age related macular degeneration AMD patients have the Dry form Geographic atrophy GA is the advanced form of Dry AMD and is caused by the degeneration of the retinal epithelial cells While GA is less common than Wet AMD it is responsible for of legal blindness in the US There is currently no FDA approved treatment ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  2. Novel Treatments to Abolish Inflammatory Mediators in Hemodialysis

    SBC: Novelmed Therapeutics Inc            Topic: 400

    DESCRIPTION provided by applicant NovelMed intends to develop a humanized anti Bb antibody as a prophylactic treatment for inflammatory responses associated with hemodialysis During this procedure blood contacts the artificial surfaces of the dialyzer activating the alternative complement pathway AP AP activation causes cellular activation and production of inflammatory mediators with po ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  3. Helium Free MRI Image Guided Radiation Therapy (IGRT) System for ViewRay Inc

    SBC: HYPER TECH RESEARCH, INC.            Topic: 102

    DESCRIPTION provided by applicant This NIH Bridge Grant will result in a conduction cooled liquid helium free MRI background magnet for a commercial image guided radiation treatment IGRT for cancer treatment The program will ensure the successful continued commercialization of our customerandapos s image guided radiation therapy IGRT system a vital cancer treatment device now treating p ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  4. DBM Anti-Proliferative Lead Small Molecules for Polycystic Kidney Disease

    SBC: DISCOVERYBIOMED, INC.            Topic: 400

    DESCRIPTION provided by applicant An important discovery and validation event occurred recently within human cell based drug discovery programs at DiscoveryBioMed Inc DBM yielding a lead class of cytostatic anti proliferative small molecules that display nanomolar potency and marked efficacy against hyperproliferative human PKD cells that create and line remodeled PKD cysts within emergen ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  5. Beta Amyloid Deposits Imaged with 18F-AZD4694 and Postmortem Histology

    SBC: Navidea Biopharmaceuticals, Inc.            Topic: NIA

    DESCRIPTION provided by applicant Navidea Biopharmaceuticals is developing F AZD as a diagnostic imaging agent to be used with PET scans to directly visualize beta amyloid A deposits in the brains of living patients A deposits in the brains of patients with dementia are diagnostic for Alzheimerandapos s Disease Al Alzheimerandapos s Disease patients have abundant deposits of A in t ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  6. [18F]NAV4694 Imaging to Identify MCI Patients at Risk for Alzheimer's Dementia

    SBC: Navidea Biopharmaceuticals, Inc.            Topic: NIA

    DESCRIPTION provided by applicant Navidea Biopharmaceuticals is developing F NAV as a diagnostic imaging agent that can be used to visualize beta amyloid A plaques in the brains of living individuals Alzheimerandapos s disease is the leading cause of dementia All patients with dementia caused by Alzheimerandapos s disease have abundant A plaques in their brains There is a great need ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  7. Fluorolog: A Rapid-Acting Ultra-Concentrated Insulin Formulation

    SBC: THERMALIN DIABETES, INC.            Topic: 200

    DESCRIPTION provided by applicant In this Phase SBIR application we seek to advance toward human clinical trials a rapid acting and ultra concentrated monomeric insulin analog of novel halogen based protein design Designated Fluorolog this analog was found in Phase I studies to exhibit rapid acting PK PD properties irrespective of protein concentration in the range mM i e from ...

    SBIR Phase II 2014 Department of Health and Human Services
  8. Phase-Cancelled, Broadband, Graphene-based Impedance Sensor

    SBC: Advratech            Topic: CBD14102

    An innovative phase-cancelled radio frequency/microwave graphene-based impedance chemical gas sensor has been demonstrated in Phase I with the record high sub-ppb sensitivity of NH3 and DMMP in air. Our sensor shows excellent selectivity for sensing NH3 and DMMP in a complex environment, and is capable of in-situ multiplexed sensing. In Phase II, the sensor will be fully integrated on a 3 glass wa ...

    SBIR Phase II 2014 Department of DefenseOffice for Chemical and Biological Defense
  9. Miniature Stimulator for Temporary Therapies

    SBC: SPR THERAPEUTICS, INC.            Topic: NICHD

    DESCRIPTION provided by applicant The goal of this project is to collect the safety and effectiveness clinical data necessary to commercialize the SMARTPATCH R system for post stroke shoulder pain PSSP The prevalence of stroke is approximately million in the US with additional persons surviving a stroke each year Moderate to severe shoulder pain develops in a quarter to a third ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  10. Acute-infarct selective cardiac MRI contrast agent

    SBC: ELGAVISH PARAMAGNETICS, INC.            Topic: NHLBI

    DESCRIPTION provided by applicant The overall goal of this project is to demonstrate the ability of our acute myocardial infarct selective paramagnetic contrast agent Gadolinium ABE DTTA to differentiate between acute and chronic infarcts in a reliable manner using contrast enhanced magnetic resonance imaging ceMRI In our Phase I data we have shown that Gd ABE DTTA exclusively highlight ...

    STTR Phase II 2010 Department of Health and Human ServicesNational Institutes of Health

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