Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until June, 2020.

  1. Continuous measurement of cell growth as an optimal tool in drug toxicity testing (Supplement)

    SBC: EnTox Sciences LLC            Topic: NCATS

    DESCRIPTION provided by applicant During the process of screening for drugs with therapeutic potential often times several candidates emerge as prime candidates with similar efficacy and the choice for a lead compound is difficult to make However peopleandapos s lives and billions of dollars may rest on the choice of which compound to bring to clinical investigation and trials Since any lev ...

    STTR Phase I 2015 Department of Health and Human Services
  2. IRE1 alpha inhibitors for Retinal Degenerative Diseases

    SBC: Optikira, LLC            Topic: N

    DESCRIPTION provided by applicant Approximately Americans suffer from vision loss due to Retinitis Pigmentosa RP Despite significant progress in elucidating the molecular genetics of RP over the past three decades no disease modifying therapies have been approved There is compelling evidence implicating endoplasmic reticulum ER stress in the pathogenesis of various forms of RP e ...

    STTR Phase I 2015 Department of Health and Human Services
  3. IRE1 alpha inhibitors for type 2 diabetes

    SBC: Optikira, LLC            Topic: 200

    DESCRIPTION provided by applicant The American Diabetes Association has declared type diabetes T D a public health crisis T D begins as a state of compensated insulin resistance frank disease develops when of insulin producing pancreatic islet cells of affected individuals undergo cell death Endoplasmic reticulum ER stress has emerged as a central underlying mechanism that drive ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  4. STTR Phase I: Mechanical Surface Treatment for High Performance Biodegradable Implants

    SBC: SURFACE INTEGRITY, LLC            Topic: BM

    The broader impact/commercial potential of this Small Business Technology Transfer (STTR) Phase I project is to shift current practices in bone fracture fixation care from using permanent metal implants to biodegradable metal implants (screws, plates, pins, rods, etc.). A promising biodegradable metal that is gaining widespread attention is magnesium. This project will advance magnesium implant te ...

    STTR Phase I 2015 National Science Foundation
  5. Interface for the collection, analysis, and visualization of simulation performance data

    SBC: Perduco Group, Inc., The            Topic: AF15AT14

    ABSTRACT: To complement capabilities of future autonomous systems, the Air Force requires interoperable tools & methodologies to design, verify, validate, assess & operate human-machine system interactions associated with autonomous and manned systems integration. Often the human performance measures and status of each simulation is reported independently making it challenging to analyze the data. ...

    STTR Phase I 2015 Department of DefenseAir Force
  6. Macromolecule Crystallization Screening Results Analysis

    SBC: IXPRESSGENES, INC.            Topic: 100

    DESCRIPTION provided by applicant Crystallization followed by subsequent structure determination is a major step in understanding the structure function relationship of macromolecules Understanding macromolecule structure has become a key part in the development of new pharmaceuticals and is a major area of NIH research Crystallization however is also the rate limiting step despite techno ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  7. Optimized Additive Manufacturing for High Dielectric Strength

    SBC: TETHERS UNLIMITED, INC.            Topic: AF15AT07

    ABSTRACT: To produce high dielectric strength insulator materials, our approach, called Optimized Additive Manufacturing for High Dielectric Strength (OAHDS), will optimize fused filament fabrication (FFF) 3D printing in order to fabricate high density parts. Currently, thermoplastics 3D printed via FFF have dielectric strengths one to three orders of magnitude lower than injection molded parts ma ...

    STTR Phase I 2015 Department of DefenseAir Force
  8. Serious STEM Games To Educate Middle School Students

    SBC: MEADOWLARK SCIENCE AND EDUCATION, LLC            Topic: OD

    DESCRIPTION provided by applicant Improving STEM focused curriculum is a primary objective of the current U S administration and is crucial for ensuring that upcoming generations receive the training and skills necessary to compete in the existing global economy To that end there is an urgent need for additional effective teaching tools able to reach a generation that requires instant access ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  9. MHZ-RATE NONLINEAR SPECTROSCOPY AND IMAGING PLATFORM FOR TRANSIENT AND NONEQUILIBRIUM FLOWS

    SBC: Spectral Energies, LLC            Topic: AF15AT20

    ABSTRACT: The objective of the proposed research effort is to demonstrate the feasibility of 100 kHz to 1 MHz nonlinear spectroscopy for measurements of molecular energy distributions, energy transfer, major species, and temperature in transient combusting and nonequilibrium flows. This will be accomplished, in part, by extending burst-mode laser technology to the fs and ps regimes for greater tha ...

    STTR Phase I 2015 Department of DefenseAir Force
  10. In Situ Quantitative Spatially-resolved Ablation Diagnostics in High-Enthalpy Flows

    SBC: Spectral Energies, LLC            Topic: AF15AT38

    ABSTRACT: The objective of the STTR Phase-I effort proposed by Spectral Energies LLC and The University of Tennessee is to demonstrate the feasibility of an in situ quantitative measurement of the products generated by the degradation of a material surface exposed to a hypersonic environment. The concept is based on a state-of-the-art diagnostic method: Coherent Microwave Rayleigh Scattering from ...

    STTR Phase I 2015 Department of DefenseAir Force
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