Award Data

DESCRIPTION (provided by applicant): The objective is to design, build, and clinically assess ParkinStep, an innovative neurotechnology that integrates wireless motion sensing, automated home-based Parkinson's disease (PD) gait and balance assessment, anddeep brain stimulation (DBS) parameter estimation using a web-based database model to integrate data across clinical centers. Following DBS ...

DESCRIPTION (provided by applicant): The proposed effort aims to develop a comprehensive wireless tracking and monitoring system for residents of Long Term Care facilities. The commercial product ElderAlertTM extends Q-Track's real-time location system totrack residents, caregivers, and medical assets within a LTC facility. ElderAlertTM directs caregivers to residents who have fallen or have ...

DESCRIPTION (provided by applicant): Polgenix, Inc. is developing an imaging instrument, the 2-photon ophthalmoscope , or 2PO , with the capability for non-invasive, repetitive and high-resolution imaging of biochemical processes within human retina.This device will allow early detection of age- and disease- related changes in the eye, long before pathological manifestations of retinal disea ...

DESCRIPTION (provided by applicant): We propose to develop and demonstrate a novel microfluidic device and assay for selection and optimization of delivery vehicles, specifically non-viral vectors for drug delivery to tumors. Tumor drug delivery is a complex phenomenon affected by several elements in addition to drug or delivery vehicle's physico-chemical properties. A key factor is tumor mic ...

DESCRIPTION (provided by applicant): Chemotherapy drugs tend to be highly cytotoxic and genotoxic, with well-documented carcinogenic, mutagenic, and teratogenic effects. Long-term occupational exposure to these highly toxic drugs presents serious health risks (e.g., cancers, infertility, miscarriages, birth defects, spontaneous abortions, and congenital malformations) to over 5.5 million healthcar ...

DESCRIPTION (provided by applicant): Research has shown that parent-targeted interventions are effective in ameliorating conduct disorders, substance abuse, HIV-risk, and related adolescent problem behaviors. During periods of economic turmoil, however, major obstacles such as affordability impede the effective delivery of support services. Ethnic minorities are especially disadvantaged with respe ...

DESCRIPTION (provided by applicant): We seek to develop a novel insulin analog to enhance the safety and efficacy of insulin pump therapy with broad application to the Artificial Pancreas Project ( smart pumps ). A proprietary approach is proposed basedon the favorable physico-chemical properties conferred by chloro-aromatic substitutions in the insulin molecule. This Phase 2 SBIR application th ...

DESCRIPTION (provided by applicant): The overall objective of this SBIR proposal is to develop and commercialize a human 3D or mini- liver bioassay system suitable for real-time analysis of metabolic functions and long-term drug toxicity profiles. At present, liver functions are mostly studied using HepG2 cell line and primary hepatocytes cultured onto collagen or polymer matrices. However, these ...

DESCRIPTION (provided by applicant): According to the World Health Organization (WHO) global eye disease survey, 14 million people are blind or severely visually impaired due to age-related macular degeneration AMD. This disease affects the central visionof adults over the age 65. Degenerative changes of the Bruch's membrane and the retinal pigment epithelium in the macula (central retina) in ...

DESCRIPTION (provided by applicant): The overall objective of this study is to develop a novel in vitro microfluidic platform to test a drug or delivery vehicle's ability to permeate the Blood-Brain Barrier (BBB). In contrast to current in-vitro models, our proposed device, SIM-BBB, comprises of a microfluidic two-compartment chamber. The chamber is designed in such a way as to permit vis ...