Award Data

Addressing PTSD and related stress reactions by Service Members and Veterans is one of our country"s most important public health challenges. Art therapy has been recognized as a powerful tool enabling"trauma survivors to symbolically express, process and contain feelings they find difficult or impossible to put in to words"(Buk, 2009). Enabling Service Members and Veterans to tell their stories ...

Dried blood spots (DBS) analysis has many advantages over standard liquid blood sample testing including: small sample size, ease of blood sampling, room temperature storage, minimal storage size requirement, and ease of shipping. Although these advantages are significant, there are still problems associated with the current DBS systems. The drying of blood spots on the DBS cards can be uneven, le ...

The proposed innovation adopts a hybrid electro-optical approach, which combines the best of the electronic and photonic approaches to achieve high sensitivity, high inter-channel stability, and large-scale integration for an integrated mm-wave receiver. Silicon photonics provides the ideal platform for this as it enables the up-conversion of the mm-wave signals from each pixel to telecommunicatio ...

Future missile systems will need to be faster, more precise, impact a larger theater of operation, and exhibit improved safety for friendly combatants. There are many technology elements that contribute to the desired level of control. In solid propellants, nanoparticle additives theoretically offer attractive improvements to specific impulse, burn rate, and combustion efficiency which can transla ...

Systima is developing an IM compliant High Performance Green Propellant (HPGP) DACS thruster that operates with a novel non-toxic monopropellant. The monopropellant has a 30% higher density-specific impulse compared to hydrazine, insensitive/ not a detonation hazard, and is commercially available off-the-shelf. In Phase I Systima will focus on development of the propellant feed and injection sys ...

Agave BioSystems proposed to develop a system of Rapidly Adaptable Nanotherapeutics (RANT) by combining advanced bioformatics, with DNA-based nanoparticles, peptide nucleic acid (PNA) antisense oligonucleotides, and cell permeating peptides (CPPs). Advanced bioinformatics computing will allow for the identification of essential and drug resistance genes within the target pathogens. These genes w ...

This firm does not wish to sumbit public abstract for the proposal High engine overall pressure ratios (OPR) enable more efficient operation for gas turbine engines, but also require higher turbine inlet temperatures. The temperature capabilities of hot section hardware have been improved through alloy development, manufacturing processes, air cooling, and thermal barrier coatings (TBC). However ...

Group II introns are a novel class of catalytic RNA molecule that are capable of site specific insertion into DNA targets. This property can be reengineered to facilitate site specific DNA integration into a wide range of DNA targets. We intend to exploit this property of group II introns to effect plasmid curing by disrupting critical sequences or proteins responsible for plasmid replication/sp ...

One major cause of the widespread of drug-resistant and virulent bacteria pathogen is the horizontal gene transfer of resistance and virulence genes in the form of plasmids. As proof-of concept for this Phase I effort, Agave BioSystems proposes to develop combinatorial therapeutics by inhibiting conserved genes involved in multiple steps of plasmid transfer and replication using peptide nucleic a ...

In this program, we will develop and prototype a new Super-Resolution Magnetic Field Microscopy (SRMFM) system that employs nitrogen-vacancy (NV) centers in diamond nanostructures to image magnetic fields with a sensitivity below 100nT/ & #8730;Hz and a spatial resolution better than 20 nm. The system consists of two primary components: (1) hardware and software for NV electron spin-based imaging ...