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SBC: IREPROGRAM, LLC Topic: ST17C001
Methods for interconversion between cell types (cellular reprogramming) are currently discovered through resource intensive trial and error. Experiments may test a multitude of transcription factors to identify correct combinations that influence cell fate. In addition, reprogramming approaches commonly use stem cell intermediates such as induced pluripotent stem cells (iPSCs), which are generated ...STTR Phase I 2018 Department of DefenseDefense Advanced Research Projects Agency
Infectious Disease Diagnostics and Differentiation of Viral vs. Bacterial Infections for Point of Care ApplicationsSBC: GENECAPTURE, INC. Topic: CBD15C001
The modern warfighter faces the constant threat of endemic infections, multi-drug resistant bacteria and Biological Warfare Agents. In order to provide accurate front-line treatment that will curtail the overuse of antibiotics, a rapid and robust moleculaSTTR Phase I 2016 Department of DefenseOffice for Chemical and Biological Defense
Host-Targeted Antiviral Drugs Providing Rapid, Scalable, Stable, Broad-Spectrum MedicalCountermeasure Against Marburg VirusSBC: EVRYS BIO LLC Topic: CBD18A002
In a pandemic or exposure to weaponized Marburg virus the morbidity, mortality and social unrest that will ensue before vaccines orMilitary operating on foreign soil as well as to the population of the US Homeland. Practically all threat agents of biological origin (except forcertain non-proteinaceous toxins, typically produced by marine organisms and fungi) have their structure and vital function ...STTR Phase I 2018 Department of DefenseOffice for Chemical and Biological Defense
SBC: CFD RESEARCH CORPORATION Topic: CBD18A001
In resource limited settings, rapid and accurate diagnosis of infections is critical for managing potential exposures to highly virulent pathogens,whether occurring from an act of bioterrorism or a natural event. This is especially important for hard to detect intracellular bacterial andalphavirus infections, that overlap symptomatically and often treated empirically due to a lack of reliable and ...STTR Phase I 2018 Department of DefenseOffice for Chemical and Biological Defense
SBC: Ocius Technologies LLC Topic: ST15C002
The objective is to design an analog (time-continuous) radiofrequency (RF) computation platform in the form of a software-defined RF integrated-circuit (IC) with supplementary digital logic for solving differential equation based simulations at speeds that are 1-2 orders of magnitude greater than available digital high-performance computation platforms. The maximum speed that the state-of-the-art ...STTR Phase I 2016 Department of DefenseDefense Advanced Research Projects Agency
Novel Extensible Design Approaches for Advanced Aircraft Composite Structural Architectures (MSC P4135)SBC: MATERIALS SCIENCES LLC Topic: ST13A006
Among the factors that inhibit the use of composite materials in both general aviation aircraft and DoD platforms are the high cost of engineering and the cost of certification. Unless manufacturers can control risk when introducing new materials and proSTTR Phase I 2013 Department of DefenseDefense Advanced Research Projects Agency
SBC: CORNERSTONE RESEARCH GROUP INC Topic: ST13A006
Federal Aviation Administration Advisory Circular 20-107B provides guidance on the achievement of compliance with Title 14 of the Code of Federal Regulations regarding airworthiness type certification requirements for composite aircraft structures necessiSTTR Phase I 2013 Department of DefenseDefense Advanced Research Projects Agency
SBC: Florida Turbine Technologies Inc. Topic: ST13A005
Pressure gain combustion has the potential to significantly improve the specific fuel consumption for gas turbine engines by realizing a pressure rise through the combustor as opposed to a pressure drop. One drawback to this form of combustion is the cyclSTTR Phase I 2013 Department of DefenseDefense Advanced Research Projects Agency
SBC: The Granville Group Inc. Topic: ST092005
Granville has designed a new satellite/spacecraft propulsion engine, GREP, delivering over 100.mN/1.0 kW of force from strong electromagnetic energy… more force magnitude and efficiency than existing propellant limited ion thrusters. And, because it uses renewable power from on-board solar/electric panels, GREP offers extended propulsion maneuver life, up to 15 years or more, substantially lon ...STTR Phase I 2010 Department of DefenseDefense Advanced Research Projects Agency
SBC: MacroCognition, LLC Topic: ST092002
We propose to develop a computational model of leadership designed to capture complex variables including cultural differences in leadership requirements along with task differences, primarily ill-defined goals, which pose leadership challenges. Rather than avoiding these kinds of complexity and developing a computational model that is unlikely to scale up, we believe there is more to be gained b ...STTR Phase I 2010 Department of DefenseDefense Advanced Research Projects Agency