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The Award database is continually updated throughout the year. As a result, data for FY22 is not expected to be complete until September, 2023.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

  1. Microfluidic High-throughput Platform for Determining of Kinetic Constants of Enzyme Variants

    SBC: CFD RESEARCH CORP            Topic: CBD10107

    Molecular biology techniques allow generating combinatorial libraries of large number of enzyme variants. However, there is currently no technology available for screening the enzyme libraries for identifying variants with improved activity for the substrate. We propose to develop a novel, microfluidic, high-throughput platform for determining kinetic constants of enzyme variants and identifying v ...

    SBIR Phase I 2010 Department of DefenseOffice for Chemical and Biological Defense
  2. In vitro Models Suitable for High-throughput Screening of Drug Toxicities in Human Tissues

    SBC: Nico Technologies Corp.            Topic: CBD10103

    The drug R&D cycle is long and very expensive. In many ways, this status quo can no longer be sustained. One of the reasons for such great cost is that the vast majority of drug candidates are screened out at the stages of animal and human trials. More efficient methods of testing of drugs at the stage of ex-vivo studies, which are substantially less expensive than animal and human testing cyc ...

    SBIR Phase I 2010 Department of DefenseOffice for Chemical and Biological Defense
  3. A Novel Microfludic Device for Drug Toxicity Studies

    SBC: CFD RESEARCH CORP            Topic: CBD10103

    Current drug discovery and development programs are severely limited by the expensive animal trials and oversimplified in vitro models. Results obtained from the in vitro models are not predictive of in vivo toxicity owing to significant difference in testing from the in vivo physiological conditions. In this context, we propose to develop and demonstrate a novel microfluidic device for quantitati ...

    SBIR Phase I 2010 Department of DefenseOffice for Chemical and Biological Defense
  4. Low/No Power Detector for Organophosphate Nerve Agents

    SBC: Luna Innovations Incorporated            Topic: CBD10101

    Organophosphate (OP) nerve agents are the most dangerous chemical warfare agents and therefore pose a significant threat. Rapid and exact identification of the OP agent involved in any hazardous material incident could significantly facilitate the administration of the most effective therapeutic and allow for appropriate measures of protection and decontamination, thereby increasing survival of t ...

    SBIR Phase I 2010 Department of DefenseOffice for Chemical and Biological Defense
  5. DEVELOPMENT OF A BIOSENSOR NANOFLUIDIC PLATFORM FOR INTEGRATION WITH TERAHERTZ SPECTROSCOPIC SYSTEM

    SBC: VIBRATESS            Topic: CBD10110

    The goal of this SBIR project is to develop and demonstrate an electrokinetically driven nanofluidic sensor device of the physical size and shape that will allow integration with a THz spectroscopic instrument. The substrate and channel surfaces within the device will be appropriate for the acquisition of THz-frequency spectroscopic features from bio-molecules (e.g., DNA, RNA, proteins) in soluti ...

    SBIR Phase I 2010 Department of DefenseOffice for Chemical and Biological Defense
  6. AC Impedance Sensor for Collective Protection Filter Residual Life Indicator

    SBC: Guild Associates, Inc.            Topic: CBD10106

    Guild Associates, Inc. proposes to develop and evaluate an active electrochemical sensor based residual life indicator (RLI) for adsorptive carbon filters. The sensing system of the RLI will operate by analyzing the electrochemical state of the carbon within the filter and evaluate the remaining adsorptive reactive capacities of the filter. The sensor design will be challenged against an array of ...

    SBIR Phase I 2010 Department of DefenseOffice for Chemical and Biological Defense
  7. Residual Life Indicator for Adsorptive and Reactive Single-Pass Filtration Systems

    SBC: MORPHIX TECHNOLOGIES, INC.            Topic: CBD10106

    In peacetime environments, concerns over improbable encounter with agent threats are supplanted by the need to understand and assess the performance status or residual life (RL) capacity of sorbent-based technologies used in Collective Protection (ColPro) systems. Systems such as the M98 and M48A1 run continuously and therefore sample large volumes of outside air over their lifetime. It is well- ...

    SBIR Phase I 2010 Department of DefenseOffice for Chemical and Biological Defense
  8. Affinity Matrix System for Large-Scale Protein Purification

    SBC: Luna Innovations Incorporated            Topic: CBD12102

    Though vast improvements have been made in various protein expression platforms, limitations arise in the implementation of current purification methods. Traditional chromatographic methods are time intensive, carry heavy material costs, and are difficult to scale - reducing the benefits achieved in protein expression. Affinity-binding methods are promising for scale-up and swiftness of purificati ...

    SBIR Phase I 2013 Department of DefenseOffice for Chemical and Biological Defense
  9. An automated, high throughput, resin-free device for large scale protein purification

    SBC: CFD RESEARCH CORP            Topic: CBD12102

    Protein manufacturing is of paramount importance to chemical and biological defense applications. High-throughput protein purification is a critical need for rapidly scaling the target protein product. Existing purification methods primarly rely on synthetic-resin based chromatography, which is time-consuming, labor-intensive, expensive, and consequently, ill-suited for developing rapid countermea ...

    SBIR Phase I 2013 Department of DefenseOffice for Chemical and Biological Defense
  10. Rapid Sample Transport in Austere Environments

    SBC: Piasecki Aircraft Corporation            Topic: CBD12108

    Piasecki Aircraft proposes to meet the challenge of delivering a biological or chemical sample maintained at less than -20 deg Celcius over a range of up to 1000 miles with a precision landing with a portable unmanned aerial system capable of a vertical takeoff, cruise flight range typical of a fixed wing platform, and able to perform a precision landing. The system consists of a lifting quadrotor ...

    SBIR Phase I 2013 Department of DefenseOffice for Chemical and Biological Defense
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