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Award Data

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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. A single dose long-acting non-addictive polymer conjugate formulation of buprenorphine that provides immediate and prolonged analgesia for post-operative pain

    SBC: SERINA THERAPEUTICS INC            Topic: NINDS

    PAProject Summary Abstract SERis a long acting polymer pro drug of buprenorphine that is being developed to treat postoperative pain following major surgeries such as bunionectomyabdominoplastythoracotomy and knee and hip surgerySERhas no biological activity by itselfbut when administered in vivo by subcutaneous injection it enters the vascular compartment where a plasma esterasebutyrylcholinester ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  2. A SAFE AND COMPACT NEONATE TO ADULT NEUROIMAGING MRI SYSTEM

    SBC: ADVANCED IMAGING RESEARCH, INC.            Topic: 101

    NIH SBIR PAw o Clinical Trials A Safe and Compact Neonate to Adult Neuroimaging MRI System The intriguing human brain is the most imaged end organ non invasivelywithout ionizing radiation using magnetic resonance imagingMRIHigh spatial resolution brain MRI is an established diagnostic tool to assess injury mechanisms affecting newborn growth and the adult human connectomeTo predict neurodevelopmen ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  3. Antithrombotic Protein C Activator for Hemodialysis

    SBC: Aronora, Inc            Topic: y

    Project Summary Although potent antithrombotic drugs are availableall inadvertently target vital hemostatic mechanismsresulting in dose limiting hemorrhagic toxicity that restricts their useDue to a lack of safe thromboprophylaxisthrombotic thromboembolic blood vessel occlusions and vascular device failures remain among the leading causes of death and severe chronic disability in the U SConsequent ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  4. Novel DNA Polymerase Inhibitors as Gram-Positive Antibacterial Agents

    SBC: CRESTONE, INC.            Topic: NIAID

    DESCRIPTION (provided by applicant): The alarming increase in incidence of infections caused by drug-resistant bacteria has created an urgent need for new antibacterial agents. We have discovered and optimized a novel class of antibiotics targeting PolC, the replicative DNA polymerase in Gram-positive bacteria. These agents exhibit broad spectrum activity against Gram-positive bacteria, including ...

    SBIR Phase I 2010 Department of Health and Human Services
  5. Stem Cells for Treating Acute Stroke

    SBC: SANERON CCEL THERAPEUTICS, INC.            Topic: 999

    ABSTRACT SUMMARY In previous studies we identified novel non hematopoietic umbilical cord blood stem cellsnhUCBSCsthat could be expanded to high passages and exhibit restorative properties following ischemic brain injury repairWe found that the high passaged cells were equivalentif not even betterthan the low passaged nh UCBSCsThis finding suggests that these cells can serve as a source of highly ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  6. Disease Modifying Biologics for Rheumatoid Arthritis

    SBC: Novelmed Therapeutics Inc            Topic: NIA

    DESCRIPTION (provided by applicant): Nearly 70 million people in the US suffer from arthritis related conditions[1, 2]. Of these, rheumatoid arthritis (RA) cases constitute approximately 3 million. RA is a chronic systemic inflammatory disease that primarily results in erosive destruction of articular joints with additional variable extra-articular effects. The growing elderly population coupl ...

    SBIR Phase I 2010 Department of Health and Human Services
  7. High-Field MR-Compatible Dense Array EEG using Polymer Thick Film Technology

    SBC: Electrical Geodesics, Inc.            Topic: NINDS

    DESCRIPTION (provided by applicant): The long-term objective of the proposed project is to design a low-profile, high-resistive, MRI-compatible dense array EEG sensor net for simultaneous dEEG/fMRI recordings in fields as high as 7 Tesla. This novel sensor net (256-channel InkNet) will use innovative conductive ink leads printed on polymer thick film (PTF) developed at the Analog Brain Imaging Lab ...

    SBIR Phase I 2010 Department of Health and Human Services
  8. Instrumentation enabling a 16-fold decrease in oligonucleotide cost

    SBC: APDM, INC.            Topic: NIA

    DESCRIPTION (provided by applicant): Although balance and gait disorders are one of the most common and devastating chronic medical problems of older people, especially those with chronic neurological diseases, clinicians or clinical researchers do not measure balance and gait frequently, accurately, or sensitively. Our long-term goal is to develop and commercialize a unique system called the Hom ...

    SBIR Phase I 2013 Department of Health and Human Services
  9. Pediatric Head Models for Improved Imaging of Neurological Development

    SBC: Electrical Geodesics, Inc.            Topic: NINDS

    DESCRIPTION (provided by applicant): While it is well known that the brain undergoes rapid developmental changes from birth to early childhood, remarkably little is understood about the relationship between changes in brain size and composition and normal cognitive development. Yet we now know that several potentially debilitating disorders, among them the Autism Spectral Disorders, Attention Defi ...

    SBIR Phase I 2010 Department of Health and Human Services
  10. Automation of quantitative DIC microscopy for 3D live-cell imaging using programm

    SBC: BOULDER NONLINEAR SYSTEMS, INC.            Topic: NCRR

    DESCRIPTION (provided by applicant): The primary objective proposed is to utilize Boulder Nonlinear System's (BNS) spatial light modulator (SLM) technology to automate the Cogswell group's recently-developed quantitative DIC microscope (Q-DIC) and make it accessible to biologists in the marketplace. Q-DIC is a full-field (non-scanning) phase imaging technique which provides optical path length mea ...

    SBIR Phase I 2010 Department of Health and Human Services
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