Award Data

During altitude-induced hypoxia, operator cognitive and physical capacity degrades, compromising individual and team performance. Cognitive degradation is linked to falling brain energy levels, increased reliance on anaerobic energy production and lactate accumulation. Ketones are the evolutionary alternative substrate to glucose for brain metabolic requirements; previous studies demonstrated that ...

DESCRIPTION (provided by applicant): In the past years, we have shown that human umbilical cord blood cells (HUCBC, U-CORD- CELL ) provide cognitive recovery in animal models of neurodegenerative disease. Infusion of HUCBC resulted in reduced infarct volume as well as in rescue of behavioral benefits in an animal model of stroke. We further showed that HUCBC infusion proved to be beneficial in ani ...

Glioblastoma (GBM) is the most lethal form of adult brain cancers with a median survival of andlt;15 months despite aggressive standard chemoradiation. GBM are formed by GBM stem-like cells (GSCs) - a major contributor to tumor recurrence and a natural focus for therapeutic development. There are two main reasons responsible for treatment failure: 1) high intra- and inter-tumor cellular and molecu ...

Protocols used for communication suffer bloat from a variety of sources, such as support for legacy features or rarely used (and unnecessary) functionality. Traditionally, the Navy subscribes to a blanket adoption of a standard protocol "as is". Unnecessary features are active and can be accessed by both internal and external systems creating security vulnerabilities. PJR Corporation's (PJR's) Pha ...

Additive manufacturing is a disruptive new manufacturing paradigm that hold tremendous potential for creation of novel designs and introduction of novel new alloy systems. However, much of this potential remains unrealized due to a lack of robust material properties databases. Accurate calibration of materials models and robust part qualification and certification regimes both will require massive ...

The Internet of Things (IoT) connects people, data, and "things" (e.g., software, sensors, platforms), facilitating the translation of information into actions. Although naval platforms’ networks and communication suites have evolved significantly in the past few years to support such required connectivity, one of the greatest technical challenges still facing the military community is the proce ...

DESCRIPTION (provided by applicant): Becoming a mother is a significant transition in a woman's life. This transition can precipitate major changes in health behaviors, like physical activity. Once a woman has a child she is much less likely to participate in regular, moderate to vigorous physical activity compared to women without children. Thus, new mothers are at risk for future weight gain and ...

DESCRIPTION provided by applicant The overall goal of this project is to demonstrate the ability of our acute myocardial infarct selective paramagnetic contrast agent Gadolinium ABE DTTA to differentiate between acute and chronic infarcts in a reliable manner using contrast enhanced magnetic resonance imaging ceMRI In our Phase I data we have shown that Gd ABE DTTA exclusively highlight ...

Type 1 Diabetes (T1D) affects an ever growing population. While this disease typically has been associated with juveniles, the disease in adult populations is rapidly increasing. The defining clinical component is insulin loss, which occurs because of sustained inflammation in the islets. At present there is no means to prevent or reverse insulin loss. A major inflammatory pathway in T1D that cont ...

West Coast Solutions (WCS) proposes the development of the SSC-X Stirling cryocooler to enable the deployment of infrared (IR) payloads on small satellite platforms. We achieve extreme miniaturization (