Award Data

Opportunity: Guayule, a US native plant, is the only alternate rubber crop with an established, mechanized, agronomic system. Problem: Low rubber yields and lack of effective resin and bagasse coproduct valorization, have prevented widespread adoption by American farmers and processors. Rubber is only made when the cytoplasmic monomer pool (isopentenyl-pyrophosphate; IPP) is larger than that requi ...

The use of continuous glucose monitors can be an invaluable management tool for patients afflicted by glycemic variability due to critical illness or trauma. Maintaining stable glucose levels enhances health and lowers care costs, and individuals equipped with continuous glucose data have significantly improved outcomes. Profusa has developed highly miniaturized, injectable, tissue-like, glucose s ...

As unmanned aircraft systems (UAS) become more prevalent there is an increasing desire to automate UAS navigation and control. To enable future UASs to perform a wider variety of missions, the they must be able to complete autonomous relative navigation to accomplish missions. Current technologies rely heavily on GPS measurements, which are undesirable since GPS signals may be unavailable in many ...

Stottler Henke proposes PaCT, leveraging our related past work in computer vision and machine learning. Drawing from techniques used in ExPATSS, a Phase II SBIR effort slated for transition to the Naval fleet, PaCT will perform bacterial characterization using features derived from the phenotype of the bacteria. PaCT will predict bacterial characteristics such as pathogenicity, antibiotic resistan ...

This project will deliver, in Phase 1, aptamers build from an artificially expanded genetic information system (AEGIS) that bind to at least four of five antimicrobial targets: amphotericin, voriconazole, colistin, gentamicin, and meropenem. These aptamers will be shown in a prototype to bind these targets at relevant concentrations over a relevant dynamic range in 50 L blood samples. In Phase 2, ...

Septic shock is a significant worldwide health problem that affects millions, but is complicated to treat since many of the signs and symptoms are non-specific and common to other non-infectious sources of systemic shock. Patient care would be improved by a rapid test to monitor key biomarkers and determine whether antibiotic use is appropriate. We propose to deliver a quantitative, multiplexed ...

In this SBIR proposal, ProbiusDx aims to develop a non-invasive, point of care diagnostic technology for characterizing host-pathogen interactions during acute infections afflicting warfighters within a resource-constrained setting; specifically we will develop a broad-spectrum platform to assay for multiple markers that define differing phases of progression in sepsis, beginning with the occurren ...

Galois and Dan Boneh of Stanford offer Talaria, a research project and prototype architecture of a secure, decentralized messaging and transaction platform. Talaria addresses four concerns for such platforms: resilience, scalability, security, and transparency.Talaria uses a decentralized, redundant, and distributed server-side architecture to provide resiliency. Talaria provides scalability by us ...

Combining Internet-style addressing with Blockchain technology, the Cryptographic Double Ratchet algorithm, distributed data resources, and universal cryptographic validation of all data and all other resources, creates a private network infrastructure designed for total information assurance. Data safety and tamper proofing are included from the ground up. All data is always encrypted, in such a ...

Stealth Software Technologies propose a novel messaging and transaction platform that is distributed, survivable and robust even under continuous attack. The platform provides privacy to message contents and participants by encrypting all messages, and utilizing cutting-edge zero-knowledge techniques for providing message/transaction authentication while preserving privacy. All messages will be lo ...