Award Data

PROJECT SUMMARYABSTRACTHigh blood pressureor hypertensionis an important public health challenge because of its high prevalence and its role in increasing risk for a variety of other diseasesAccording to the American Heart Associationapproximatelyout of everyadults in the United States has hypertensionand the situation is projected to worsen with the percentage rising to approximatelyof the adult ...

Abstract. Hispanic Americans are the largest and fastest growing US minority and, over coming decades, will show the largest relative increase in Alzheimer’s disease (AD) incidence of any ethnic group. However, Spanish-speaking Hispanics have been largely excluded from clinical trials and research studies for several reasons: (1) Only 5.5% of US neuropsychologists have sufficient fluency to admi ...

Psychiatric disorders give rise to aberrant patterns of activity within the complex neural circuits of our brains. Yet, the exact nature of these abnormal patterns is often unknown to developers of new treatments. The goal of this project is to enable circuit-oriented research of neuropsychiatric diseases using rodent disease models. The long-term objective is to catalyze the discovery of new ther ...

PROJECT ABSTRACT Advancing age is often accompanied by a decline of key neuromodulatory centers of the brain that support adaptive neuroplasticity. Deterioration of the underlying neurophysiology of the brain predisposes the individual to pathological and age-related cognitive decline. We propose to deploy a computerized cognitive training program (INHANCE) developed via two successful SBIR-funded ...

Project Summary/Abstract Advanced Medical Electronics Corporation and our partners propose to develop a Socially-Assistive Robot (SAR) system for persons with dementia (PWD),(mild cognitive impairment, Alzheimerandapos;s disease, or other dementias), who are living in assisted living facilities. The proposed system uses Augmented Intelligence (AI) to communicate with the PWD in natural language. T ...

Project Summary Our understanding of neuropsychiatric disorders is undergoing a paradigm shift away from simple models emphasizing neurotransmitter imbalance towards more sophisticated theories based on abnormalities in neural circuit function. This is especially important for understanding disorders like Schizophrenia and PTSD, which defy simple biochemical explanations, but are now known to invo ...

ABSTRACT: , Trans Women Connected: a mobile app delivered sexual health promotion program During the past two decades, the HIV epidemic has severely impacted transgender women in the U.S. According to the CDC persons have the highest HIV incidence of any risk group (56% of Black transgender women are living with HIV), and discrepancies between self-reported prevalence and HIV testing data indicate ...

Project Summary/Abstract Prospective evaluation of a surgical solution for breast cancer-associated lymphedema The proposed project will complete remaining key research and technology requirements that are needed to commercialize a ground-breaking interventional device for treating secondary lymphedema -- a chronic and debilitating disease that currently has no cure and impacts an estimated 15-30% ...

Stroke is the world’s greatest healthcare burden for which few treatment options are available. The long-term objective of the applicant, Nervive, Inc., is to bring to market a non-invasive medical device, the VitalFlow stimulator, as an emergency treatment for ischemic stroke. The VitalFlow is a novel technology that activates the autonomic components of the facial nerve using pulsed magnetic e ...

ABSTRACT Funding is requested to support essential steps required to commercialize 3P-001, a medical device thatgenerates medical grade nitric oxide (NO) from air. NO is a pulmonary vasodilator to treat hypoxic respiratoryfailure (HRF) in neonates (blue babies) and pulmonary hypertension in patients having cardiothoracic surgery (CTS). Third Pole’s value proposition is that availability of a tan ...