Award Data

PROJECT SUMMARY Post-thrombotic syndrome (PTS) is a chronic debilitating condition characterized by limb swelling and discomfort, hyperpigmentation, skin ulcers, and impaired quality of life. It occurs within 2 years of deep vein thrombosis (DVT) treatment in 50-60% of patients with iliofemoral thrombosis and in 30-50% of all DVT patients regardless of thrombosis location (1). Even with pharmacolo ...

PROJECT SUMMARY Mesenchymal stem cells (MSC) are in clinical development for cardiovascular, neurologic, orthopedic, and other indications. Ossium is developing a novel source of MSC from vertebral bodies (vbMSC). Genetic modification of vbMSC using lentiviral vector (LV) has the potential to improve the therapeutic potential. Understanding how genetic modification might alter the vbMSC phenotype ...

The concern identified in the DARPA Impact of Cockpit Electro-Magnetics on Aircrew Neurology (ICEMAN) STTR Opportunity Announcement is that strong electromagnetic fields (EMF) within modern Department of Defense (DoD) aircraft cockpits may be degrading pilot performance and potentially leading to mishaps including loss of life.  Proposers received funding for a Phase 1 effort responding to the an ...

It is unknown how cockpit EM and RF exposures might affect pilot performance and physiology.  Animal, human, and physics research indicate that a pathway for such exposures to impact human physiology exists via aggregations of magnetite, a ferromagnetic nanocrystal.  Aggregations of magnetite have been found in many animal tissues, including in the human brain; they have been linked to magnetore ...

Special Operations Forces (SOF) operators are among the most elite, and highly qualified individuals in the U.S. military. Extraordinary physical and mental demands are placed upon them, to include superior performance standards, high operational tempos, and the pressure to excel in extreme environments for extended periods of time. In the SOF community, serious injuries are the norm rather than t ...

PROJECT SUMMARY The goal of the proposed project is to evaluate the potential of HBI-002, a novel oral formulation of carbon monoxide (CO), as a neuroprotective agent in Parkinson’s disease (PD). A growing body of research suggests that low doses of CO - and the heme oxygenase (HO) enzymes that generate endogenous CO - protect against neuronal cell loss in PD, and epidemiologic studies have asso ...

Project Summary/Abstract Deep learning has transformed medical image analysis by delivering clinically meaningful results on challenging problems like prostate cancer detection and lung screening. In pathology, industry is making significant invest- ments to develop deep learning tools for diagnostic use in clinical labs. FDA approval of whole-slide digital pathology images (WSIs) for use in prim ...

Abstract Magnetic resonance imaging (MRI) is critically important for pediatric care and the unusable data caused by patient motion has been estimated to cost $1.4B per year in the United States alone. Currently, a radiologist assesses if the images are satisfactory or not, but an MRI technologist does the imaging, and coordination of communication between the two is costly and slow. We propose to ...

The objective of this proposal is to examine a novel technique called improved Synchronization Modulation Electric Field (i-SMEF) in protection of donor kidneys and improvement of transplanted graft functions. We will apply the i-SMEF on donor kidneys during cold storage and evaluate the transplanted graft function following kidney transplantation in mice.We have developed a novel technique, named ...

Radical prostatectomy (RP) is a commonly used treatment option for localized prostate cancer, which carries a high risk for development of erectile dysfunction (ED) because of cavernous nerve (CN) injury. Even newer, nerve-sparing, robotic procedures do not convincingly improve erectile function (EF) outcomes after RP. In addition, ED resulting from RP is often refractory to treatment by orally ad ...