Award Data

DESCRIPTION (provided by applicant): Osteoarthritis (OA) is the leading cause of chronic disability in the United States. A clinical goal in the treatment and prevention of OA is to develop replacement cartilage using tissue engineering (TE) technologies. Although TE cartilage presently lacks the mechanical stability of native cartilage, studies have demonstrated that mechanical stability can be e ...

As underwater threats continue to evolve, active sonar systems and operators must evolve with them, requiring improvements to sources, receivers, signal processing algorithms, and search mission planning applications in order to maintain and improve detection rates. Any improvements in the latter requires a detailed and accurate understanding of the acoustic underwater environment, and the underly ...

DESCRIPTION: We identified the Myrica cerifera (Southern Bayberry) extract using a systematic screen as a potent reducer of the structural protein tau, which accumulates in a group of diseases called the tauopathies . The most prevalent tauopathy is Alzheimer's disease, for which there is renewed interest in the identification of tau- based therapeutic approaches to treat this devastating d ...

ABSTRACT Infection is a serious and potentially fatal complication of surgery to deliver cardiovascular implantable electronic devicesCIEDsi epacemakers and implantable cardioverter defibrillatorsUntreated device related infection is associated with mortality rates as high asCurrentlyonly one antibiotic impregnated mesh has been FDA approved for placement in surgical incisions to reduce infections ...

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Northwest UAV Propulsion Systems proposes using our purpose built heavy fuel engine designed and built in the USA for small unmanned aerial systems in the tier 2 & 3 class. We will be adding a lightweight ceramic material set combined with FEA (Finite Element Analysis) and heavy fuel atomizer (IRAD Project) to create a lightweight engine for a SUAS or STUAS class UAVs. The Ceramic material set is ...

DESCRIPTION (provided by applicant): We propose a novel and competitive urinary tract silicone Foley catheter made from a proprietary polymeric formulation to effectively reduce catheter-associated urinary tract infections (CAUTI) via nitric oxide (NO) release. Preliminary studies show that the device will be able to: (1) continuously deliver NO at rates enough to maintain bactericidal properties ...

There is a need to create an automated, adaptive, real time coaching module that can integrate the Conning Officer Virtual Environment (COVE) along with the associated Intelligent Tutor System (COVE-ITS) and the Conning-Officer Ship Handling Assessment (COSA) together. By automating the evaluation process, Surface Warfare Officers (SWOs) will have the opportunity to use the COVE simulations more f ...

DESCRIPTION (provided by applicant): Patient Provider Communications will develop EloquenceTM based on data acquired from research conducted by the University of Michigan School of Nursing addressing the specific aims and hypothesis. This project extends the research team's preliminary findings on the development of technology to improve communication with critically ill patients using patient des ...

Advances in electronically controlled injection technologies for diesel engines have provided a method to improve medium- to heavy-duty engine performance through increased injection pressures, multiple injections, and injection rate shaping. Although these injection systems have been primarily limited to larger engines, the ability to rapidly and precisely meter fuel for smaller engines is partic ...