Award Data

In a pandemic or exposure to weaponized Marburg virus the morbidity, mortality and social unrest that will ensue before vaccines orMilitary operating on foreign soil as well as to the population of the US Homeland. Practically all threat agents of biological origin (except forcertain non-proteinaceous toxins, typically produced by marine organisms and fungi) have their structure and vital function ...

In resource limited settings, rapid and accurate diagnosis of infections is critical for managing potential exposures to highly virulent pathogens,whether occurring from an act of bioterrorism or a natural event. This is especially important for hard to detect intracellular bacterial andalphavirus infections, that overlap symptomatically and often treated empirically due to a lack of reliable and ...

We propose a novel two-dimensional mass spectrometry (2D-MS) technique based on ion trap arrays to identify illicit and designer drugs. This approach will give an unprecedented multiplex advantage for miniature mass spectrometry, allowing novice field technicians to rapidly identify drugs affecting the central nervous system based on both the m/z ratio and fragmentation pattern of an ion. Towards ...

CMC Pharmaceuticals, Inc. (Cleveland, OH) is proposing developing a stable, combination product of two small molecule drug candidates as a counter measure to chemical warfare nerve agents (NA). The combination product is expected to exploit complementary pharmacological profiles for optimal muscarinic receptor blockade and anticholinergic activity within the peripheral and central nervous system. ...

Safe and efficient air ionization and filtration technology compatible to biodefense applications is of paramount importance. Current ionization methods are energy-intensive, costly, prone to ozone generation, or inefficient, and consequently ill-suited for building protection applications. To overcome these issues, we propose to develop and demonstrate a novel bioaerosol ionization and collection ...

Hook and loop closures in Army uniforms have been identified as the critical sources of leaks in protective clothing/equipment, which limits the overall protective capability of the ensemble. New closure systems capable of providing both the shear and peel strengths demonstrated by hook and loop systems as well as hermetic sealing against any vapor permeation across the closure need to be develope ...

The NGA requires an automatic, unsupervised SAR feature extraction (AUFE) technique, that can ultimately be deployed for geospatial analysis, modeling, and target detection. Our proposed “SAR Unsupervised and Robust Feature ExtractoR” (SURFER) solution includes in Phase I: (1) a sound and deterministic assessment of the underlying RF phenomenology and SAR processing theoretical basis for effec ...

Traditional active 3D imaging systems, such as airborne and terrestrial lidar scanners, use a transmitter and receiver typically co-located on the same platform and connected in synchronous communications. However, recent advances in laser, detector, and airborne systems technology have opened the door to smaller, higher-performance and significantly lower-cost airborne lidar systems in which it i ...

Signature Research, Inc. (SGR) and Michigan Technological University (MTU) propose a Phase I STTR effort to develop a learning algorithm which exploits the spatio-spectral characteristics inherent within IR imagery and motion imagery.Our archive of modelled and labeled data sets will allow our team to thoroughly capture the variable elements that will drive machine learning performance.The overall ...

NLP pipelines available today are getting robust for general language modeling purposes. But domain-specific data, abbreviations and lingos, and text about time or space still need a lot of tuning and training that are well beyond application of standard tool sets. Deep learning for recommendation engines is quite new, and all recommender systems, in particular for specially trained users, tend to ...