Award Data

Methods for interconversion between cell types (cellular reprogramming) are currently discovered through resource intensive trial and error. Experiments may test a multitude of transcription factors to identify correct combinations that influence cell fate. In addition, reprogramming approaches commonly use stem cell intermediates such as induced pluripotent stem cells (iPSCs), which are generated ...

Glucose abnormalities significantly affect patient morbidity and mortality. Currently, glycemic control is achieved via medications and exogenous insulin regimens that are costly both in terms of qualified personnel and consumables. Furthermore, none of these approaches are curative. Strategies under development such artificial pancreases do not necessarily address these limitations because they w ...

Federal Aviation Administration Advisory Circular 20-107B provides guidance on the achievement of compliance with Title 14 of the Code of Federal Regulations regarding airworthiness type certification requirements for composite aircraft structures necessi

Pressure gain combustion has the potential to significantly improve the specific fuel consumption for gas turbine engines by realizing a pressure rise through the combustor as opposed to a pressure drop. One drawback to this form of combustion is the cycl

We propose to develop a computational model of leadership designed to capture complex variables including cultural differences in leadership requirements along with task differences, primarily ill-defined goals, which pose leadership challenges. Rather than avoiding these kinds of complexity and developing a computational model that is unlikely to scale up, we believe there is more to be gained b ...

Granville has designed a new satellite/spacecraft propulsion engine, GREP, delivering over 100.mN/1.0 kW of force from strong electromagnetic energy… more force magnitude and efficiency than existing propellant limited ion thrusters. And, because it uses renewable power from on-board solar/electric panels, GREP offers extended propulsion maneuver life, up to 15 years or more, substantially lon ...

Among the factors that inhibit the use of composite materials in both general aviation aircraft and DoD platforms are the high cost of engineering and the cost of certification. Unless manufacturers can control risk when introducing new materials and pro

Opportunity: Guayule, a US native plant, is the only alternate rubber crop with an established, mechanized, agronomic system. Problem: Low rubber yields and lack of effective resin and bagasse coproduct valorization, have prevented widespread adoption by American farmers and processors. Rubber is only made when the cytoplasmic monomer pool (isopentenyl-pyrophosphate; IPP) is larger than that requi ...