Award Data

DESCRIPTION (provided by applicant): The objective of this grant proposal is to perform a clinical study which will allow the first foldable and injectable artificial cornea, the KeraKlear, to be used in the United States market for treatment of corneal blindness. This device may be implanted through an incision size that is approximately 1/10th the size of the incision that is required for the mo ...

DESCRIPTION provided by applicant The objective of this grant proposal is to perform a clinical study which will allow the first foldable and injectable artificial cornea the KeraKlear to be used in the United States market for treatment of corneal blindness This device may be implanted through an incision size that is approximately th the size of the incision that is required for the mo ...

DESCRIPTION provided by applicant High throughput Electrophysiological Purification Array HEPA for cell based therapies Abstract Patient specific reprogrammed somatic cells induced pluripotent stem cells or iPSCs have raised hope for revolutionary regenerative treatments for heart lung and blood diseases and drug development applications For example these iPS cells can be differentiated ...

DESCRIPTION provided by applicant Attention Deficit Hyperactivity Disorder ADHD is a highly prevalent disorder incurring billions of dollars of costs annually for which there is a rel need for additional non pharmacologic treatments Deficits in maintaining attentional control manifest as inconsistent intra individual performance on sustained attention tasks with periods of normal performan ...

DESCRIPTION provided by applicant There is a need for new technologies to enable multiplexed analysis of collections of biomarkers in biological samples We propose to develop a novel assay format for detecting and analyzing many biomarkers simultaneously In order to do this we will develop reagents and methods and validate the approach using a model system If successful our long term goal i ...

DESCRIPTION provided by applicant Tuberculosis TB disease which results from infection with Mycobacterium tuberculosis Mtb is a leading cause of infectious morbidity and mortality in children andlt years old worldwide In TB endemic regions in which the vast majority of the worldandapos s annual million adult cases of TB disease reside children andlt years old account for ...

DESCRIPTION provided by applicant The overall goal of this phase SBIR proposal is to position our novel biologic GE for human clinical trials in allergic disease though the completion of critical preclinical development research activities GE a genetically engineered human fusion protein consisting of portions of the human gamma Fc linked to portions of the human epsilon Fc chain has unique mechan ...

DESCRIPTION provided by applicant The goal of this research is to develop an innovative prototypical medical device treatment system capable of detecting and visualizing three dimensional shape and tip position of a biopsy needle during Magnetic Resonance Imaging MRI or other image assisted interventional radiological procedures This work will be done in collaboration with interventional rad ...

DESCRIPTION (provided by applicant): We propose an innovative microtechnology-enhanced surgical device that solves a significant therapeutic bottleneck in the treatment of lens cataract in children. As the leading cause of childhood blindness, lens cataract interferes with the optical performance of the eye and if untreated, results in lifelong deficits in visual perception. The first step in pedi ...

DESCRIPTION provided by applicant Complete achromatopsia is an autosomal recessive inherited congenital disorder of retinal cone photoreceptors Patients with complete achromatopsia experience extreme light sensitivity and daytime blindness and best visual acuity under non bright light conditions is usually or worse and generally stable over time In addition to poor acuity hypersensit ...