Award Data

Summary Worldwide, only 1 out of 70 patients with corneal endothelial dystrophies and injuries receive a corneal transplant due to the limited corneal donor pool, the need for advanced surgical facilities and talent, and expense. RashmiVu is developing a stem cell based regenerative technology that addresses this large unmet global need through a paradigm shift, wherein treatment could be as simpl ...

ABSTRACT: Cutaneous vascular malformations (CVM), such as port wine stain (PWS) which occurs in 0.3–0.5% of newborns, are often a cause of great concern to patients for both medical and cosmetic reasons. Laser irradiation with flashlamp-pumped pulsed dye lasers, i.e. photothermolysis therapy (PTT), is currently the gold standard treatment for PWS. Most patients with PWS, however, fail to clear c ...

Project Summary Immunoregulation, i.e., balanced expression of regulatory and effector T cells, is thought to be compromised in modern high-income settings due in part to reduced contact with commensal and environmentally derived bacteria, also known as “old friends”. Failed immunoregulation is thought to be one factor contributing to recent increases in stress-related and chronic inflammatory ...

PROJECT SUMMARY/ABSTRACT Lack of exercise is a major cause of secondary health conditions, especially for people with paralysis, for whom participation in physical activity is especially difficult. Hybrid functional electrical stimulation (H- FES) exercise enables vigorous, total body physical activity for people with paralysis. However, existing H-FES devices are neither affordable nor accessible ...

PROJECT SUMMARY The ability of dying cells to activate antigen presenting cells (APCs) is carefully controlled to avoid unwarranted inflammatory responses. Thus, tumor cells avoid aggravating APCs by efficiently simulating regular dying cells which following phagocytosis do not trigger inflammatory responses required for efficient cytotoxic T lymphocyte (CTL) priming. However, dying tumor cells co ...

Abstract Significance: Peritonitis remains a significant challenge in the management of end stage renal disease (ESRD) for patients on peritoneal dialysis (PD) and contributes significantly to morbidity and mortality. More than half of these infections result from bacteria originating on skin or mucous membranes, suggesting patient or caregiver contamination as the source of infections. Furthermor ...

PROJECT SUMMARY/ABSTRACT Ten percent of the approximately four million infants born in the United States each year are born premature (andlt;37 weeks gestational age). Preterm birth prior to the maturation of critical neonatal body systems results in prolonged hospitalizations that impose an annual societal cost burden of $26 billion. Achievement of the ability to fully orally feed is often the la ...

Virtual EM is proposing a method to achieve orders of magnitude improvement in computational efficiency in full-wave CEM codes by using high-order curved elements. Virtual EM’s own commercial product VirAntenn™ will provide the CEM setting for both developing and implementing the new capability in Phase I and Phase II, respectively. Using multi-wavelength long cells with high-order basis forms ...

Project Summary: The main goal of this research project is to develop a new line of new stereotaxic devices for small animal research that outperforms existing devices in terms of accuracy, reproducibility, and ease of use. Advancing a tool such as an electrode, injection pipette or optical fiber through a small hole in the cranium, sometimes over long distances, and placing it precisely in a part ...

Summary The recent proliferation of next-generation sequencing (NGS) - based methods for the analysis of gene expression, chromatin structure and protein-DNA interactions has created tremendous opportunities for gaining novel insights into basic biology, health, and disease. However, analysis of the resulting data requires computational expertise that many traditional biologists do not possess. He ...