Award Data

DESCRIPTION (provided by applicant): Cancer treatment today is in need of tumor-specific and effective therapies that do not harm the patient and thereby compromise treatment efficacy and prolong recovery time. A multi-modal therapeutic and imaging agent t hat does not damage healthy living tissue would have tremendous benefit to researchers and victims of this deadly disease. Nanomaterials have t ...

DESCRIPTION (provided by applicant): A high percentage of the ~ 470,000 children born prematurely each year in the US require intravenous feeding after birth because they do not tolerate oral feeding. This is accomplished with a total parenteral nutrition (TPN) solution, which is prepared from component solutions: small and large volume parenterals (SVPs and LVPs). Aluminum (Al) is a common conta ...

DESCRIPTION (provided by applicant): This project will support research and further development of a novel commercializable product designed to reduce and mitigate the psychological impact of a major disaster. The long-term objective of this project is to provide a scientifically supported, highly accessible, culturally relevant, anonymous multi- media system that fills the current gap in mental ...

DESCRIPTION (provided by applicant): Over five hundred years of contact with European culture has had a profound impact on American Indian communities, with destructive policies implemented in the service of assimilation efforts that broke up the extended family and community. The strains of history pressing on American Indian families are reflected in research indicating weakened family connecti ...

DESCRIPTION (provided by applicant): Biologically and clinically relevant proteomics data can only be generated if organ or tissue samples investigated consist of homogeneous cell populations, in which no unwanted cells of different types and/or developmen t stages obscure the results. Thus, several tissue microdissection technologies have been developed to provide a rapid and straightforward meth ...

DESCRIPTION (provided by applicant): Prior descriptive research has examined family involvement in residential long-term care, and a handful of nursing and psychosocial interventions have attempted to facilitate family involvement and residents' social int egration in nursing homes. However, the intensity and potential intrusiveness of these interventions may make them difficult to administer as r ...

DESCRIPTION (provided by applicant): Human umbilical cord blood is a rich source of hematopoietic stem cells that can be used to re-populate the blood and immune systems. In preliminary studies we have identified a novel population of non-hematopoietic cel ls that exhibit extensive self-renewal and markers characteristic of stem cells. We postulate that these cells can be used to repair the brain ...

DESCRIPTION (provided by applicant): Recent studies indicate that the prevalence of overweight and obesity in children is very high (about 25-30 percent), and the incidence is increasing, especially among minority African- American and Hispanic children. O besity in childhood is associated with a high risk of continued obesity into adolescence and adulthood. This is of great public health signific ...

DESCRIPTION (provided by applicant): The overall goal of Discovery Genomics, Inc. is to develop the Sleeping Beauty transposon system for human gene therapy. To achieve this to treat hemophilia, we must be able to direct uptake and long-term expression of therapeutic genes in targeted tissues such as the liver. Only one method of plasmid delivery has been effective for high-level gene expression ...

DESCRIPTION (provided by applicant): Without blood, tissue dies. The goal of this project is to develop very small sensors - looking something like this, -- that can be placed flat on the wall of a blood vessel and measure its blood flow. This new device i s called a patch-sensor, and this STTR Phase I is to establish its proof-of-concept by making one and demonstrating that it works in a living a ...