Award Data

DESCRIPTION (provided by applicant): Submerged Electro-Spark Deposition (SESD, US patent pending), developed at Advanced Surfaces And Processes, Inc., is a surface modification technique. Any conductive surface can be modified with regards to surface texture and chemical composition. The objective of the present proposal is to use SESD to incorporate appreciable amounts of bone mineral elements, i ...

DESCRIPTION (provided by applicant): Hepatitis C Virus (HCV) causes a persistent infection in most humans exposed to the virus. HCV infection in time can lead to cirrhosis and hepatocellular carcinoma. Although the annual number of newly infected patients has dropped significantly over the past decade, about 4 million people are currently persistently infected in the USA. There is presently no un ...

DESCRIPTION (provided by applicant): The goal of this Phase I STTR proposal is to demonstrate the feasibility of a novel prosthetic venous valve design concept. One of the ultimate goals in vascular surgery is to develop a successful prosthetic venous valve to replace defective valves in patients with chronic venous insufficiency (CVI). More than 8 million Americans suffer from the debilitating c ...

DESCRIPTION (provided by applicant): The overall goal of the proposal is to develop an automated data acquisition system for non-invasive quantitative cancer detection, screening, and monitoring, based on highly sensitive low volume real time PCR technique and capillary electrophoresis, apply this system for quantitative analysis of the telomerase activity and gene expression in single cancer c ...

DESCRIPTION (provided by applicant): About 250,000 Americans a year die of coronary heart disease without being hospitalized, and most of these are sudden deaths caused by cardiac arrest. Due to similarities of cardiovascular physiology and genetic structure to humans, biomedical research has increasingly employed the mouse in models of human disease, which has provided powerful tools for investig ...

DESCRIPTION (provided by applicant): Determining which amino acid residues of a protein form the binding site for a small molecule ligand, or that are present at the interface of a protein-protein complex, is difficult to identify from the crystal structure of the apo-protein. Recently, we have developed mass spectrometric methods coupled with heavy isotope labeling for mapping the location of ac ...

DESCRIPTION (provided by applicant): Amyotrophic lateral sclerosis (ALS) is a fatal degenerative disease affecting motor neurons in the spinal cord, brainstem and cortex. We have previously shown that transplanting neuronal cells into the spinal cord delays the onset of motor symptoms in the G93A mouse model of ALS, but developing a potential treatment strategy around a committed neuronal cell or ...

DESCRIPTION (provided by applicant): This program is aimed at developing a new class of drugs effective against most aggressive and a poorly curable hormone independent form of prostate cancer (CAP). Failure of androgen ablation therapy is rarely associated with the loss of the androgen receptor (AR) signaling by hormone-independent CaP. AR pathway in such tumors remains constitutively active rega ...

DESCRIPTION (provided by applicant): Since the late 1980's there has been a sharp rise in the number of children and adolescents presenting to emergency departments (EDs) for psychiatric issues. Given that mental health issues account for 1.6% - 5.0% of all pediatric ED visits, and that Emergency Medical System's (EMS) staffs are the first to interact with these youth, the assessment of psychiatri ...

DESCRIPTION (provided by applicant): The objective of the STTR program "Educating Schools and Families with ToxRAP over MPEG-4" is to educate teachers, school-age children and their families on the identification and evaluation of environmental health problems so that they have the knowledge and skills to reduce their exposure to potential pollutants and prevent environment-related illnesses and d ...