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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Long-Duration, Eye-in-the-Sky Monitoring for Airfield Threat Detection

    SBC: DEFENSE RESEARCH ASSOCIATES, INC.            Topic: AF06204

    In today’s Urban-Warfare Command and Control, Intelligence, Surveillance and Reconnaissance (C2ISR) environment, current sensor platforms have a limited operational capability due to power consumption and recharge times. Many times these sensor packages are found to be unsuitable for many battlefield environments due strictly to their endurance limitations. Much of the research done to date has ...

    SBIR Phase II 2010 Department of DefenseAir Force
  2. Development of a Personalized Medicine Interface for the Safe and Effective Treat

    SBC: PHARMACOGENETICS DIAGNOSTIC LABORATORIES            Topic: NHLBI

    DESCRIPTION (provided by applicant): Improvements in the safety and efficacy of warfarin therapy will result from intelligent application of knowledge derived from inherited characteristics (CYP2C9 and VKORC1) of individual patients, only when this knowledge is applied through a standardized interventional approach. The fundamental pharmacologic influences of CYP2C9 and VKORC1 have been unequi ...

    SBIR Phase II 2010 Department of Health and Human Services
  3. Technologies for the Rapid Curing of Composite Parts (PVCI08-007-1)

    SBC: Vector Composites, Inc.            Topic: AF083C068

    Bismaleimide (BMI) 5250-4 and epoxy 977-3 material systems are used in F-35 aircraft composite components fabricated via autoclave. Alternative out-of-autoclave processes can reduce manufacturing costs by lowering capital and tooling costs and providing faster cure cycles, if properties can be maintained. Feasibility of the Quickstep out-of-autoclave process for 5250-4 and 977-3 material systems h ...

    SBIR Phase II 2010 Department of DefenseAir Force
  4. Refinement of lead compounds to modulate water permeability through AQP4

    SBC: AEROMICS, Inc.            Topic: NINDS

    DESCRIPTION (provided by applicant): Cerebral edema (and its counterpart in the spinal cord) is a major contributor to the damage caused by stroke, traumatic brain injury, traumatic spinal-cord injury, and bacterial meningitis. Stroke alone is the third leading cause of death in the USA and the leading cause of disability. Unfortunately, few treatment options are available for cerebral and spinal- ...

    SBIR Phase II 2010 Department of Health and Human Services
  5. Therapeutic Potential of Ex vivo expanded Human Cord Blood derived CD133+ cells i

    SBC: Arteriocyte, Inc.            Topic: NHLBI

    DESCRIPTION (provided by applicant): Critical Limb Ischemia (CLI) is a common problem that often results in major limb amputation. Circulating endothelial progenitor cells likely play a role in the pathogenesis of CLI; the number and function of these cells that are mobilized from the bone marrow are reduced in the elderly and diabetics, groups at high risk for CLI. Allogenic Umbilical Cord Blood ...

    SBIR Phase II 2010 Department of Health and Human Services
  6. BUCKI- Bridge for Usable Collaborative Knowledge Integration

    SBC: The Design Knowledge Company            Topic: AF083026

    BUCK-I defines an architecture for an appropriate work-centered support environment, creates an innovative method for human knowledge indexing, defines collaboration technologies and methods, and introduces tools to manage workflow. It is open source, cross platform, and cross-operating system technology. BENEFIT: Successful completion of BUCK-I would provide TDKC with a commercializable produc ...

    SBIR Phase II 2010 Department of DefenseAir Force
  7. Creation of hyperactive transposons for mutagenesis in rodents

    SBC: TRANSPOSAGEN BIOPHARMACEUTICALS, INC.            Topic: NCRR

    DESCRIPTION (provided by applicant): The rat is a favored model for many types of human disease for which mice are not suitable. As opposed to the mouse, rats and humans also share more similarity in their cytochrome P450 genes, making the rat a more useful model for toxicology and pharmacology studies. The rat is also a favored model for diabetes, arthritis, behavioral disorders (including drug a ...

    SBIR Phase II 2010 Department of Health and Human Services
  8. Positive Airway Pressure Gas Modulator- A Novel Method to Treat Central Sleep Ap

    SBC: CLEVELAND MEDICAL DEVICES, INC.            Topic: NHLBI

    DESCRIPTION (provided by applicant): Sleep apnea is a major public health problem but traditional treatments have focused mostly on resolving obstructive sleep apnea (OSA) as demonstrated by the plethora of obstruction-motivated therapies like positive airway pressure, oral appliances, and others. However, more troubling forms of sleep apnea exist like those that are mediated by chemoreflex instab ...

    SBIR Phase II 2010 Department of Health and Human Services
  9. SapC-DOPS nanovesicles for Treating Glioblastoma Multiforme

    SBC: BEXION PHARMACEUTICALS, INC.            Topic: NCI

    DESCRIPTION (provided by applicant): Our goal is to develop a new molecular entity with a novel mechanism of action for targeting and eliminating glioblastoma multiforme (GBM, high grade glioma), a deadly and invasive brain tumor with no effective treatment. Of the 12,000 patients expected to be diagnosed with GBM this year, most will succumb within the first year. Clearly, there is an urgent ...

    SBIR Phase II 2010 Department of Health and Human Services
  10. Pilot Physiologic Assessment System (PPAS)

    SBC: ORBITAL RESEARCH INC            Topic: N091018

    Orbital Research Inc in collaboration with NASA Glenn Research Center (NASA GRC), Kent State University (KSU) and Massachusetts Institute of Technology (MIT) will design and test the second generation, Pilot Physiologic Assessment System (PPAS-2) as part of the Phase I option and Phase II SBIR program funded by the U.S. Navy. The system will be a comprehensive bio-monitoring suite that acquires ph ...

    SBIR Phase II 2010 Department of DefenseNavy

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