Award Data

PROJECT SUMMARY In this Phase I Small Business Technology TransferSTTRprojecta team of researchers at Cincinnati Childrenandapos s Hospital Medical CenterCCHMCwill work with the engineering team at NeoViewIncto design and build novel body coil and incubator prototypes for aTesla Neonatal Intensive Care UnitNICUMRI systemThese components will play a central role in NeoViewandapos s neonatal MRI pro ...

PROJECT SUMMARY Despite rapid transport to appropriate facilitiesmany trauma patients needlessly die in the first hour of careTrauma is the leading cause of death for Americans under the age ofand greatest cause of potential life years lost before the age ofexceeding that of either cancer or heart diseaseUp toof traumatic deaths may be preventableIt is estimated that miscommunication is the leadin ...

PROJECT SUMMARY ABSTRACTThis project s long term purpose is to adapt an existing telepresence robotVecna s VGofor remote care of persons living at home with early stage Alzheimer s and related dementiasADRDIt responds to the NIA s call for development of robots to support care management and independent livingpromote social engagementreduce lonelinessand assist family members and professionals in ...

ABSTRACT Approximately individuals live with upper limb loss loss of at least one hand in the US Fortunately prosthetic devices have advanced considerably in the past decades with the development of dexterous anthropomorphic hands However potentially the most promising used control strategy myoelectric control lacks a correspondingly high level of performance and hence the use of dexterous hands r ...

Falls are a significant source of early morbidity and mortality in the aging populationyet the neurologicalsensoryand motor changes that lead to increased fall risk often escape early identification and interventionVital signs are commonly used in clinical settings to assess the cardiovascular systemblood pressureheart rateimmune systembody temperatureand the respiratory systemrespiratory rateto e ...

Pathological hallmarks of Alzheimerandapos s diseaseADinclude extracellular deposits of Apeptidesintraneuronal aggregates of abnormally phosphorylated tau protein and neuroinflammationMost proposed AD disease modifying therapies have focused on strategies that reduce brain Aamyloid or tau pathological accumulationHoweversuch approaches have been unsuccessful in late stage AD clinical trials and ma ...

Byovermillion people in the USA will be diagnosed with Alzheimerandapos s related dementia at an annual treatment cost near $billionTo contain the escalation in healthcare costsnew treatments are needed to relieve the underlying genetic causes and risk factors leading to dementia onsetIn simple animal modelsdrugs have been found that lead to lifespan extensionYet the underlying genetic mechanisms ...

Aging Frailty is a biologically driven geriatric syndrome of multisystem physiological decline that is distinct from normal aging and disproportionately increases vulnerability to adverse clinical outcomesFrailty has an overall prevalence ofof thoseyears and olderand there is growing awareness in the geriatric community to diagnose and treat this conditionas it is not an inevitable consequence of ...

Post-mortem evidence shows that CDK5, a major kinase for tau and amyloid precursor protein, is hyperactive in the brains of patients with AD. Multiple genome wide association studies link CDK5 alleles to AD. Elegant genetic mouse(5xFAD) and human stem cell-derived neuron studies demonstrate the CDK5 hyperactivity is required (rather than just a correlation) for progression of AD pathology. CDK5 is ...

ABSTRACT The Development and Evaluation of Computerized Olfactory Training ProgramCOTfor Cognitive Decline in Preclinical and Early Alzheimer s DiseaseADis a project to develop a home based brain stimulation device for prevention of AD progression in preclinical and early ADThe success of enriched odor environment for reversal of AD pathology in animals spurred high hopes for translation of olfact ...