Award Data

NON-TECHNICAL SUMMARY: This is a phase I SBIR proposal by Adenosine Therapeutics for 6 months of support to synthesize and evaluate novel compounds as agonists of equine A2A adenosine receptors. Some of these compounds have been found to be very effective in reducing rodent mortality form endotoxin or from E. coli-induced sepsis. Circulating endotoxin (lipopolysaccharide) is correlated with the pr ...

The objective of the Ballistic Missile Defense System (BMDS) is todetect, identify, and track targets using sensor observations, andengage the lethal objects using interceptors.To achieve the desired level of effectiveness, the system mustdistinguish between the lethal and non-lethal objects.Object identification is performed by a discrimination systemthat relies on a tracking system to associate ...

RESEARCHERS ARE CONSTRUCTING TEST PANELS OF FIBER-REINFORCED-POLYMER HONEYCOMB (FRPH), INSTRUMENTED WITH STRAIN GAUGES AND ACOUSTIC SENSORS FOR CONDUCTING NON-DESTRUCTIVE EVALUATION (NDE) ACOUSTIC EMISSION (AE) AND PHYSICAL LOAD TESTING. FRPH STRUCTURAL ELEMENTS ARE HIGH-STRENGTH, LIGHTWEIGHT, CORROSION-RESISTANT, TOUTH, AND RESILIENT; THEY CAN BE MACHINE-MANUFACTURED USING A HIGH-VOLUME, CONTINUO ...

DESCRIPTION (provided by applicant): The major objective of the proposed project is to develop methodology that will allow fast and efficient detection of infectious prion proteins prior to the onset of clinical symptoms. This includes the detection of infectious prions in mortal products, early ante-mortem diagnostic of the prion diseases, and developing experimental approaches allowing deline ...

The feasibility of a new approach that will accelerate the modeling of problems involving rarefied gas dynamics is established. The proposed hybrid approach solves the Boltzmann equation directly using a carefully designed discrete-velocity model and adiscrete Monte Carlo collision process with several extensions that accelerates its computational capability in comparison with direct simulation M ...

DESCRIPTION (provided by applicant): Myogen's goal is to discover novel disease-modifying therapies for heart failure (HF). Approximately 700,000 individuals are affected each year by HF, which is a common endpoint of many cardiovascular diseases. The annual health care costs for HF patients in the United States is estimated at $10-40 billion. Clearly, novel treatment approaches are necessary. Ani ...

DESCRIPTION (provided by applicant): Many high schools use a graphing scientific calculator to assist students in math and science courses. These calculators have a built-in screen and displays graphs and perform scientific functions. These calculators are used widely in higher math (Algebra I and beyond) and science courses. They are a valuable tool for high school teachers and students. Unfor ...

DESCRIPTION (provided by applicant): Many high schools use a graphing scientific calculator to assist students in math and science courses. These calculators have a built-in screen and displays graphs and perform scientific functions. These calculators are used widely in higher math (Algebra I and beyond) and science courses. They are a valuable tool for high school teachers and students. Unfor ...

72158S03-I Interactions with unwanted electrons are a major limiting factor in the performance of ion accelerators. A main source of these electrons is collisions at grazing incidence between the ions and the beam pipe walls. Computer modeling could be used to examine this problem, but the codes in the heavy-ion fusion community presently do not have the capability to model grazing-incidence co ...

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