Award Data

NON-TECHNICAL SUMMARY: This is a phase I SBIR proposal by Adenosine Therapeutics for 6 months of support to synthesize and evaluate novel compounds as agonists of equine A2A adenosine receptors. Some of these compounds have been found to be very effective in reducing rodent mortality form endotoxin or from E. coli-induced sepsis. Circulating endotoxin (lipopolysaccharide) is correlated with the pr ...

The primary goals of the Phase I research plan are to develop a prototype absorbable stent for use in mid-tubal reanastomosis and to evaluate the effectiveness of this device in a rabbit experimental model. Mechanical design criteria will be determined by making measurements of luminal caliber and tubal compliance in freshly excised rabbit oviducts. The stent will be designed to 1) accommodate dis ...

DESCRIPTION (provided by applicant): The major objective of the proposed project is to develop methodology that will allow fast and efficient detection of infectious prion proteins prior to the onset of clinical symptoms. This includes the detection of infectious prions in mortal products, early ante-mortem diagnostic of the prion diseases, and developing experimental approaches allowing deline ...

The feasibility of a new approach that will accelerate the modeling of problems involving rarefied gas dynamics is established. The proposed hybrid approach solves the Boltzmann equation directly using a carefully designed discrete-velocity model and adiscrete Monte Carlo collision process with several extensions that accelerates its computational capability in comparison with direct simulation M ...

DESCRIPTION (provided by applicant): Many high schools use a graphing scientific calculator to assist students in math and science courses. These calculators have a built-in screen and displays graphs and perform scientific functions. These calculators are used widely in higher math (Algebra I and beyond) and science courses. They are a valuable tool for high school teachers and students. Unfor ...

DESCRIPTION (provided by applicant): Many high schools use a graphing scientific calculator to assist students in math and science courses. These calculators have a built-in screen and displays graphs and perform scientific functions. These calculators are used widely in higher math (Algebra I and beyond) and science courses. They are a valuable tool for high school teachers and students. Unfor ...

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FIELD INVESTIGATIONS NATIONWIDE REVEAL THE PRESENCE OF NON-AQUEOUS PHASE LIQUIDS IN THE SUBSURFACE. OILY FUELS HAVE BEEN RELEASED TO THE SUBSURFACE BY LEAKY TANKS, WHILE AT OTHER SITES, CONTAMINATION HAS RESULTED FROM CHEMICAL SPILLS AND IMPROPER WASTE DISPOSAL PRACTICES. DUE TO THE COMPLEXITIES OF MULTIPHASE FLOW AND TRANSPORT PROCESSES, RESEARCHERS HAVE ONLY RECENTLY BEGUN TO DEVELOP SIMULATION ...

JRM proposes a novel context-dependent, signature-based approach to improve the automation and quality of material-classification of imagery and arbitrary n-channel remote-sensed data. In the Phase I, JRM will design three key components: (1) anautomated N-channel signature-predictive material classification algorithm, (2) a pixel-material spatial-correlation refinement algorithm and (3) an iter ...

THE OBJECTIVE IS TO MODIFY COLLAGEN TO INCREASE AND CONTROL THE RESORPTION TIME IN IMPLANTS WITHOUT CAUSING INFLAMMATION. THE SPECIFIC AIM IS TO DEVELOP A COLLAGEN MEMBRANE FOR PERIODONTAL USE WITH A RESORPTION TIME OF ABOUT TWELVE WEEKS AND NEGLIGIBLE INFLAMMATORY RESPONSE. A NONINFLAMMATORY LONG RESORPTION TIME COLLAGEN WOULD ALSO FIND APPLICATION IN ORTHOPEDICS, BREAST IMPLANTATION, CONTROLLED ...