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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Cytochlor/cytofluor: New Tumor Targeted Radiosensitizer

    SBC: HALOGENETICS            Topic: N/A

    DESCRIPTION (provided by applicant): Cytochlor Technology is about to enter a Phase I trial as a radiosensitizer of tumors of the oral cavity and oropharynx with NCI supervision. Our objective is to demonstrate Cytochlor's safety, selectivity and possible efficacy (although efficacy is not the goal of a Phase I trial). Our goal is to move Cytochlor Technology to a mutliinstitutional Phase II clini ...

    STTR Phase I 2004 Department of Health and Human ServicesNational Institutes of Health
  2. Data acquisition system for noninvasive cancer detection

    SBC: Biophotonics Corporation            Topic: N/A

    DESCRIPTION (provided by applicant): The overall goal of the proposal is to develop an automated data acquisition system for non-invasive quantitative cancer detection, screening, and monitoring, based on highly sensitive low volume real time PCR technique and capillary electrophoresis, apply this system for quantitative analysis of the telomerase activity and gene expression in single cancer c ...

    STTR Phase I 2004 Department of Health and Human ServicesNational Institutes of Health
  3. Remote focusing through spatial light modulation for multifocal multiphoton micro

    SBC: BOULDER NONLINEAR SYSTEMS, INC.            Topic: NIMH

    DESCRIPTION (provided by applicant): Nonlinear optical microscopy techniques (such as two-photon florescence) are being used to acquire volumetric (i.e. three dimensional) images that probe several hundred microns into scattering tissue. These techniques are being combined with fast acquisition schemes to allow imaging of live, moving specimens at high NA. This combination allows for high-resoluti ...

    STTR Phase I 2013 Department of Health and Human ServicesNational Institutes of Health
  4. Medication Administration Error Prevention System

    SBC: SOFTWARE TECHNIQUES, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The Goal of the project is to decrease medication administration errors without increasing staff work, time or effort. Phase I is to demonstrate feasability; Phase II is to prototype and test the system and develop a commercialization plan. The goal of Phase I of this project is to: Engineer a device to monitor medication administration in real time, including: ...

    STTR Phase I 2004 Department of Health and Human ServicesNational Institutes of Health
  5. In vivo Clinical Coherence Confocal Microscope

    SBC: LUCID, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Phase I Reflectance confocal microscopy images the cellular and structural morphology of tissue in-vivo or ex-vivo without the need for histological processing. Existing reflectance confocal microscopes use single wavelength laser to generate gray scale intensity images. The goals of this proposal are to build and characterize a coherence reflectance c ...

    STTR Phase I 2004 Department of Health and Human ServicesNational Institutes of Health
  6. Development of a novel whole blood coagulation assay

    SBC: HEMODYNE            Topic: N/A

    The inability to adequately monitor the effects of newer, potent anticoagulants is increasingly apparent. These powerful drugs have a very narrow therapeutic window. This is especially true in high-risk populations such as those with hepatic and renal dysfunction. Conventional monitoring parameters (i.e., PT, aPTT, INR) do not adequately measure or predict efficacy or toxicity for many of these ne ...

    STTR Phase I 2004 Department of Health and Human ServicesNational Institutes of Health
  7. Gene Enhanced Tissue Engineering for Bone Regeneration

    SBC: TISSUEGENESIS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The development of novel and improved technologies for bone regeneration is desirable in many clinical applications, especially in dental and craniofacial reconstruction and fracture repair. Optimal bone regeneration requires the interaction of three components at the site of injury. These include: the presence of appropriate cell type(s) with bone regenerative ...

    STTR Phase I 2004 Department of Health and Human ServicesNational Institutes of Health
  8. Non-Peptide Somatostatin Agonist Analgesics

    SBC: RFE PHARMA, INC.            Topic: N/A

    The overall goal of this proposal is to determine that peripheral somatostatin (SST) receptor activation by NISAs (Non-peptide Imidazolidindione Somatostatin Agonists) can control nociceptor excitability, reducing peripheral sensitization and promoting analgesia. Peripheral sensitization of nociceptors is a key element that not only underlies primary hyperalgesia in the periphery but also contribu ...

    STTR Phase I 2004 Department of Health and Human ServicesNational Institutes of Health
  9. High Productivity Eukaryotic Cell Culture Technology

    SBC: MEDICAL ROBOTICS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The goals of this project are to develop a method to increase eukaryotic cell production and cell quality for research and drug discovery. We have preliminary data that demonstrates that we have developed a neutral buoyancy hydrogel based microcarrier process that can dramatically increase the density, viability, and diversity of cells available to researchers ...

    STTR Phase I 2004 Department of Health and Human ServicesNational Institutes of Health
  10. Application of CDX-MDM in Pre-Clinical Model of Murine Pulmonary Emphysema

    SBC: Covenant Therapeutics LLC            Topic: NHLBI

    DESCRIPTION (provided by applicant): The objective of this proposal is to exploit a newly discovered anti-inflammatory function involving the aminopeptidase activity of the leukotriene A4 hydrolase for the treatment of pulmonary emphysema. The leukotrieneA4 hydrolase is a dual-functioning enzyme with dichotomously opposing functions. As an epoxide hydrolase, it catalyzes the conversion of leukotri ...

    STTR Phase I 2013 Department of Health and Human ServicesNational Institutes of Health
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